Rationale: Bilateral sonication with focused ultrasound (FUS) in conjunction with
microbubbles has been shown to separately reduce amyloid plaques and …

Abnormal changes of the microvasculature are reported to be key evidence of the
development of several critical diseases, including cancer, progressive kidney disease, and …

Given strong regional specialization of the brain, cerebral angiogenesis may be regionally
modified during normal aging. To test this hypothesis, expression of a broad cadre of …

Vascular contributions to early cognitive decline are increasingly recognized, prompting
further investigation into the nature of related changes in perivascular spaces (PVS). Using …

Previous studies suggest white matter (WM) integrity is vulnerable to chronic hypoperfusion
during brain ageing. We assessed~ 0.7 million capillary profiles in the frontal lobe WM …

MR-guided focused ultrasound (MRgFUS) can temporarily permeabilize the blood-brain
barrier (BBB), noninvasively, to allow therapeutics access to the central nervous system …

The present and future research efforts in cognitive neuroscience and psychophysiology rely
on the measurement, understanding, and interpretation of blood oxygenation level …

Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Reduced cerebral blood flow impairs cognitive function and ultimately causes irreparable
damage to brain tissue. The gliovascular unit, composed of neural and vascular cells …

There is a critical need for reliable quantitative biomarkers to assess functional brain
alterations in mouse models of neuropsychiatric diseases, but current imaging methods …