Abstract Background: Li-Fraumeni syndrome is a dominantly inherited disorder
characterized by early-onset breast cancer, sarcomas, and other cancers in children and …

Abstract The Li-Fraumeni cancer family syndrome is manifested by susceptibility to breast
cancer, sarcomas, and other neoplasms in children and young adults. The present study …

The goal of this review is to demonstrate the effective interaction of epidemiologic methods
and molecular genetics in the identification of familial cancer predisposition. The example …

Germ-line p53 mutations have been identified in most families with Li-Fraumeni syndrome
(LFS). For germ-line p53 mutation carriers, there is considerable variability with respect to …

In 1969 Li and Fraumeni identified, from a systematic study of 648 children with
rhabdomyosarcomas, five families in which a sibling or a cousin was affected by sarcoma (Li …

Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks
for a broad spectrum of cancers including early-onset cancers. Five cancer types account for …

Purpose: Li-Fraumeni syndrome is a rare hereditary cancer syndrome associated with
germline mutations in the TP53 gene. Although sarcomas, brain tumors, leukemias, breast …

BACKGROUND Li‐Fraumeni syndrome (LFS) is an autosomal dominant cancer
predisposition syndrome characterized by a very high lifetime cancer risk and an early age …

Abstract The Li-Fraumeni familial cancer syndrome was initially described in 1969 in a
retrospective epidemiologic review of more than 600 pediatric sarcoma patients. The clinical …

Background. Acquired mutations in the p53 tumor-suppressor gene have been detected in
several human cancers, including colon, breast, and lung cancer. Inherited mutations …