In pulmonary sarcoidosis, the typical T helper 1-mediated immune response in the lungs has
been proposed to be co-ordinated by regulatory T cells; however, their exact role needs to …

Sarcoidosis is a multisystem granulomatous disease of unknown etiology characterized by
the expansion of activated oligoclonal CD4+ T cells and macrophages at sites of disease. To …

Recent data suggest that the newly discovered cytokine IL-15 cooperates with IL-2 in driving
T cell-mediated immune responses. The aim of this study was to determine the role of IL-15 …

Rationale: Cystic fibrosis (CF) is characterized by bronchoalveolar neutrophilia and
submucosal lymphocytosis. We hypothesized that Th17 lymphocytes are part of this …

Sarcoidosis is a systemic granulomatous disease that develops due to the Th1, Th17 and
Treg lymphocytes disturbance. There is an assumption, that B cells and follicular T-helper …

Abstract Background T helper 17 (Th17) cells can recruit neutrophils to inflammatory sites
through production of IL-17, which induces chemokine release. IL-23 is an important inducer …

BACKGROUND: Chronic hypersensitivity pneumonitis is characterized by pulmonary
inflammation and fibrosis in response to repeated inhalation of mainly organic antigens. It is …

Cystic Fibrosis (CF) is the most common lethal genetic disease in the Caucasian population
and typically results in the development of bronchial inflammation, bronchiectasis, the …

Activated pulmonary CD4+ T lymphocytes of the Th-1 type are essential for the inflammatory
process in sarcoidosis, and IFN-γ production is crucial for the characteristic granuloma …

We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced
by human mycobacterial infection. Remarkably,> 20% of specific cytokine-producing CD4+ …