Targeting the oxytocin system: new pharmacotherapeutic approaches

D Gulliver, E Werry, TA Reekie, TA Katte… - Trends in …, 2019 - cell.com
Deficits in social behavioral domains, such as interpersonal communication, emotion
recognition, and empathy, are a characteristic symptom in several neuropsychiatric …

[HTML][HTML] Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study

K Daughters, ASR Manstead, K Hubble, A Rees… - PLoS …, 2015 - journals.plos.org
The use of intranasal oxytocin (OT) in research has become increasingly important over the
past decade. Although researchers have acknowledged a need for further investigation of …

Intranasal oxytocin selectively attenuates rhesus monkeys' attention to negative facial expressions

LA Parr, M Modi, E Siebert, LJ Young - Psychoneuroendocrinology, 2013 - Elsevier
Intranasal oxytocin (IN-OT) modulates social perception and cognition in humans and could
be an effective pharmacotherapy for treating social impairments associated with …

Understanding the oxytocin system and its relevance to psychiatry

S Shamay-Tsoory, LJ Young - Biological psychiatry, 2016 - biologicalpsychiatryjournal.com
Oxytocin research has experienced a remarkable resurgence over the past decade,
particularly with respect to its role in regulating social cognition and its prospects for treating …

[HTML][HTML] Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders

K Macdonald, D Feifel - Frontiers in neuroscience, 2013 - frontiersin.org
Concerns regarding a drought in psychopharmacology have risen from many quarters. From
one perspective, the wellspring of bedrock medications for anxiety disorders, depression …

Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI …

DS Quintana, LT Westlye, D Alnæs… - …, 2019 - nature.com
Little is known about how intranasally administered oxytocin reaches the brain and
modulates social behavior and cognition. Pupil dilation is a sensitive index of attentional …

Anxiolytic effects of chronic intranasal oxytocin on neural responses to threat are dose-frequency dependent

J Kou, Y Zhang, F Zhou, Z Gao, S Yao… - Psychotherapy and …, 2022 - karger.com
Introduction: Anxiety disorders are prevalent mental conditions characterized by
exaggerated anxious arousal and threat reactivity. Animal and human studies suggest an …

Modulating social behavior with oxytocin: how does it work? What does it mean?

PS Churchland, P Winkielman - Hormones and behavior, 2012 - Elsevier
Among its many roles in body and brain, oxytocin influences social behavior. Understanding
the precise nature of this influence is crucial, both within the broader theoretical context of …

Salivary vasopressin increases following intranasal oxytocin administration

O Weisman, I Schneiderman, O Zagoory-Sharon… - Peptides, 2013 - Elsevier
Extant research has documented the effects of intranasal administration of oxytocin (OT),
and to a lesser degree Arginine Vasopressin (AVP)–two structurally-related neuropeptides …

Stimuli and consequences of dendritic release of oxytocin within the brain

ID Neumann - Biochemical Society Transactions, 2007 - portlandpress.com
The brain oxytocin system has served as a distinguished model system in
neuroendocrinology to study detailed mechanisms of intracerebral release, in particular of …