Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review

M Horta, K Kaylor, D Feifel, NC Ebner - Neuroscience & Biobehavioral …, 2020 - Elsevier
Oxytocin (OT) subserves various physiological, behavioral, and cognitive processes. This
paired with the ability to administer OT with minimal and inconsistent side effects has …

Intranasal oxytocin as a potential therapeutic strategy in post-traumatic stress disorder: a systematic review

G Giovanna, S Damiani, L Fusar-Poli… - …, 2020 - Elsevier
Abstract Treatment options for Posttraumatic Stress Disorder (PTSD) are limited in terms of
available drugs and the success of psychotherapeutic interventions. Oxytocin is a peptide …

Intranasal oxytocin blocks alcohol withdrawal in human subjects

CA Pedersen, KL Smedley, J Leserman… - Alcoholism: clinical …, 2013 - Wiley Online Library
Background The neuropeptide, oxytocin (OT), has been reported to block tolerance
formation to alcohol and decrease withdrawal symptoms in alcohol‐dependent rodents …

Targeting the oxytocin system to treat addictive disorders: rationale and progress to date

MR Lee, MCH Rohn, G Tanda, L Leggio - CNS drugs, 2016 - Springer
The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning, and
memory processes. As such, there is increasing interest in oxytocin as a potential treatment …

Effects of intranasal oxytocin on steroid hormones in men and women

MM Wirth, AE Gaffey, BS Martinez - Neuropsychobiology, 2015 - karger.com
Background: Recent interest in the social and cognitive effects of intranasal oxytocin
prompts a need for understanding its physiological effects in humans. Few studies have …

[PDF][PDF] Intranasal oxytocin mechanisms can be better understood, but its effects on social cognition and behavior are not to be sniffed at

DS Quintana, JD Woolley - Biol Psychiatry, 2016 - academia.edu
The administration of intranasal oxytocin (IN-OT) has demonstrated a wide range of effects
on social behavior and cognition, which has led to its proposed use as a treatment for …

Neurochemical evidence for differential effects of acute and repeated oxytocin administration

S Benner, Y Aoki, T Watanabe, N Endo, O Abe… - Molecular …, 2021 - nature.com
A discrepancy in oxytocin's behavioral effects between acute and repeated administrations
indicates distinct underlying neurobiological mechanisms. The current study employed a …

Selective localization of oxytocin receptors and vasopressin 1a receptors in the human brainstem

SM Freeman, AL Smith, MM Goodman… - Social …, 2017 - Taylor & Francis
Intranasal oxytocin (OT) affects a suite of human social behaviors, including trust, eye
contact, and emotion recognition. However, it is unclear where oxytocin receptors (OXTR) …

Chronic intranasal oxytocin has dose-dependent effects on central oxytocin and vasopressin systems in prairie voles (Microtus ochrogaster)

CD Guoynes, TC Simmons, GM Downing, S Jacob… - Neuroscience, 2018 - Elsevier
Oxytocin (Oxt) is a neuropeptide with many functions, including modulation of social
behavior (s) and anxiety. Due to its notable pro-social effects, it has been proposed as a …

[HTML][HTML] The role of intranasal oxytocin in anxiety and depressive disorders: A systematic review of randomized controlled trials

F De Cagna, L Fusar-Poli, S Damiani… - Clinical …, 2019 - ncbi.nlm.nih.gov
Several studies have demonstrated the neuromodulating function of oxytocin (OT) in
response to anxiogenic stimuli as well as its potential role in the pathogenesis of …