Brain age and other bodily 'ages': implications for neuropsychiatry

JH Cole, RE Marioni, SE Harris, IJ Deary - Molecular psychiatry, 2019 - nature.com
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

Quantification of the biological age of the brain using neuroimaging

JH Cole, K Franke, N Cherbuin - Biomarkers of human aging, 2019 - Springer
The cosmetic and behavioural aspects of ageing become increasingly apparent with the
passing years. The individual variability in physical ageing can be immediately observed in …

Predicting age using neuroimaging: innovative brain ageing biomarkers

JH Cole, K Franke - Trends in neurosciences, 2017 - cell.com
The brain changes as we age and these changes are associated with functional
deterioration and neurodegenerative disease. It is vital that we better understand individual …

Aging biomarkers and the brain

AT Higgins-Chen, KL Thrush, ME Levine - Seminars in cell & …, 2021 - Elsevier
Quantifying biological aging is critical for understanding why aging is the primary driver of
morbidity and mortality and for assessing novel therapies to counter pathological aging. In …

Ten Years of BrainAGE as a Neuroimaging Biomarker of Brain Aging: What Insights Have We Gained?

K Franke, C Gaser - Frontiers in neurology, 2019 - frontiersin.org
With the aging population, prevalence of neurodegenerative diseases is increasing, thus
placing a growing burden on individuals and the whole society. However, individual rates of …

Brain age predicts mortality

JH Cole, SJ Ritchie, ME Bastin, V Hernández… - Molecular …, 2018 - nature.com
Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …

Brain ageing in the new millennium

JN Trollor, MJ Valenzuela - Australian & New Zealand …, 2001 - journals.sagepub.com
Objective: This paper examines the current literature pertaining to brain ageing. The
objective of this review is to provide an overview of the effects of ageing on brain structure …

The aging brain observed in vivo: Differential changes and their modifiers

N Raz - Cognitive neuroscience of aging: Linking cognitive and …, 2004 - books.google.com
Aging is a manifold of universal biological processes that, with passage of time, profoundly
alter anatomy, neurochemistry, and physiology of all organisms. Although no organs or …

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life

SR Cox, MA Harris, SJ Ritchie, CR Buchanan… - Molecular …, 2021 - nature.com
Different brain regions can be grouped together, based on cross-sectional correlations
among their cortical characteristics; this patterning has been used to make inferences about …

Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders

E Sibille - Dialogues in clinical neuroscience, 2013 - Taylor & Francis
The increased risk for neurodegenerative and neuropsychiatric disorders associated with
extended lifespan has long suggested mechanistic links between chronological age and …