Why is SIMS underused in chemical and biological analysis? Challenges and opportunities

AV Walker - Analytical chemistry, 2008 - ACS Publications
Technological developments in secondary ion MS (SIMS) have improved imaging and
molecular depth profiling. However, SIMS remains an underused technique in chemical and …

Molecular SIMS imaging; spatial resolution and molecular sensitivity: have we reached the end of the road? Is there light at the end of the tunnel?

JS Fletcher, NP Lockyer… - Surface and interface …, 2011 - Wiley Online Library
This article describes how advances in instrument development facilitate the generation of
high‐contrast secondary ion images by employing polyatomic ion beams and sampling in …

Developments in molecular SIMS depth profiling and 3D imaging of biological systems using polyatomic primary ions

JS Fletcher, NP Lockyer… - Mass spectrometry …, 2011 - Wiley Online Library
In principle mass spectral imaging has enormous potential for discovery applications in
biology. The chemical specificity of mass spectrometry combined with spatial analysis …

[HTML][HTML] Higher sensitivity secondary ion mass spectrometry of biological molecules for high resolution, chemically specific imaging

LA McDonnell, RMA Heeren, RPJ de Lange… - Journal of the American …, 2006 - Elsevier
To expand the role of high spatial resolution secondary ion mass spectrometry (SIMS) in
biological studies, numerous developments have been reported in recent years for …

[引用][C] Imaging secondary ion mass spectroscopy

KL Moore, M Schröder… - Handbook of …, 2012 - Wiley Online Library
Imaging Secondary Ion Mass Spectroscopy Page 1 709 21 Imaging Secondary Ion Mass
Spectroscopy Katie L. Moore, Markus Schröder, and Chris RM Grovenor Secondary ion mass …

[HTML][HTML] NanoSIMS for biological applications: current practices and analyses

J Nuñez, R Renslow, JB Cliff, CR Anderton - Biointerphases, 2018 - pubs.aip.org
Secondary ion mass spectrometry (SIMS) has become an increasingly utilized tool in
biologically relevant studies. Of these, high lateral resolution methodologies using the …

A new SIMS paradigm for 2D and 3D molecular imaging of bio-systems

JS Fletcher, JC Vickerman - Analytical and bioanalytical chemistry, 2010 - Springer
With the implementation of focused primary ion beams, secondary ion mass spectrometry
(SIMS) has become a significant technique in the rapidly emerging field of mass spectral …

Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS)

MK Passarelli, N Winograd - … et Biophysica Acta (BBA)-Molecular and Cell …, 2011 - Elsevier
Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the
examination and characterization of lipids directly from biological materials. The successful …

SIMS imaging in neurobiology and cell biology

P Agüi-Gonzalez, S Jähne, NTN Phan - Journal of Analytical Atomic …, 2019 - pubs.rsc.org
Secondary ion mass spectrometry (SIMS) has been increasingly recognized as a powerful
technique for visualizing molecular architectures in the fields of neurobiology and cell …

Secondary ion mass spectrometry imaging of biological cells and tissues

NP Lockyer - Electron Microscopy: Methods and Protocols, 2014 - Springer
Secondary ion mass spectrometry (SIMS) is capable of providing detailed atomic and
molecular characterization of the surface chemistry of (bio) molecular samples. It is one of a …