Background In health, nitric oxide (NO) shows high concentrations in the upper airways,
while nasal NO (nNO) is significantly lower in patients with sinonasal inflammation, such as …

Objectives: In health, nitric oxide (NO) can be measured in high concentrations in the upper
respiratory tract. It has been shown that nasal NO (nNO) is significantly lower in patients with …

Importance Sinonasal symptoms in patients suffering from cystic fibrosis can negatively
influence the quality of life and sinuses can be a niche for pathogens causing infection and …

Background Nitric oxide (NO) is produced within the respiratory tract and can be detected in
exhaled bronchial and nasal air. The concentration varies in specific diseases, being …

Introduction: Nitric oxide (NO) plays an important role in the regulation of airway caliber &
host defense against certain bacteria. NO is reduced in cystic fibrosis (CF) airways & NO …

Background Elexacaftor/tezacaftor/ivacaftor is a highly effective modulator that improves
function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein …

Airways of patients with cystic fibrosis are deficient for nitric oxide. Low nitric oxide in cystic
fibrosis has been shown to be associated with poor pulmonary function and risk of infection …

Introduction: Airway nitric oxide (FENO) in people with cystic fibrosis (CF) is lower than
normal and ivacaftor results in an early and sustained increase in FENO in treated …

The fraction of exhaled nitric oxide (F eNO) is generally lower in individuals with cystic
fibrosis (CF), compared to healthy controls. Two recent studies reported that the cystic …

Keywords: cystic fibrosis; CFTR modulator; elexacaftor; tezacaftor; ivacaftor; chronic
rhinosinusitis; sinus surgery; SNOT-22 EN cystic fibrosis CFTR modulator elexacaftor …