Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

F Zhang, C Hammack, SC Ogden, Y Cheng… - Nucleic acids …, 2016 - academic.oup.com
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain
abnormalities. How ZIKV impairs brain development and function is unclear. Here we …

ZIKV strains differentially affect survival of human fetal astrocytes versus neurons and traffic of ZIKV-laden endocytotic compartments

J Jorgačevski, M Korva, M Potokar, M Lisjak… - Scientific reports, 2019 - nature.com
Malformations of the fetal CNS, known as microcephaly, have been linked to Zika virus
(ZIKV) infection. Here, the responses of mammalian and mosquito cell lines, in addition to …

The impact of ZIKV infection on gene expression in neural cells over time

MMS Rodrigues, AMP Júnior, ER Fukutani… - Plos one, 2024 - journals.plos.org
Zika virus (ZIKV) outbreak caused one of the most significant medical emergencies in the
Americas due to associated microcephaly in newborns. To evaluate the impact of ZIKV …

Zika virus vertical transmission induces neuroinflammation and synapse impairment in brain cells derived from children born with Congenital Zika Syndrome

C Benazzato, F Lojudice, F Pöehlchen, PEC Leite… - Scientific Reports, 2024 - nature.com
Zika virus (ZIKV) infection was first reported in 2015 in Brazil as causing microcephaly and
other developmental abnormalities in newborns, leading to the identification of Congenital …

Astrocytes derived from neural progenitor cells are susceptible to Zika virus infection

EI Rubio-Hernández, M Comas-García… - PLoS …, 2023 - journals.plos.org
Zika virus (ZIKV) was first isolated in 1947. From its isolation until 2007, symptoms of ZIKV-
caused disease were limited (eg, fever, hives, and headache); however, during the epidemic …

The impact of Zika virus in the brain

FB Russo, PCB Beltrão-Braga - Biochemical and biophysical research …, 2017 - Elsevier
The recent outbreak of ZIKV in Brazil called the attention of the world because the effects of
viral infection in the brain under development in fetuses. Consequences of vertical infection …

The transcriptional and protein profile from human infected neuroprogenitor cells is strongly correlated to Zika virus microcephaly cytokines phenotype evidencing a …

MC Lima, LR Mendonça, AM Rezende… - Frontiers in …, 2019 - frontiersin.org
Zika virus (ZIKV) infection during pregnancy is associated with microcephaly, a congenital
malformation resulting from neuroinflammation and direct effects of virus replication on the …

Strain-dependent consequences of Zika virus infection and differential impact on neural development

FT Goodfellow, KA Willard, X Wu, S Scoville, SL Stice… - Viruses, 2018 - mdpi.com
Maternal infection with Zika virus (ZIKV) during pregnancy can result in neonatal
abnormalities, including neurological dysfunction and microcephaly. Experimental models of …

Zika virus infection dysregulates human neural stem cell growth and inhibits differentiation into neuroprogenitor cells

P Devhare, K Meyer, R Steele, RB Ray, R Ray - Cell death & disease, 2017 - nature.com
The current outbreak of Zika virus-associated diseases in South America and its threat to
spread to other parts of the world has emerged as a global health emergency. A strong link …

In utero infection of Zika virus leads to abnormal central nervous system development in mice

W Zhang, YW Tan, WK Yam, H Tu, L Qiu, EK Tan… - Scientific reports, 2019 - nature.com
Abstract The World Health Organization has declared ZIKA virus (ZIKV) a global public
health emergency, prompted by the association of ZIKV infections with severe brain …