Zika virus infects intermediate progenitor cells and post-mitotic committed neurons in human fetal brain tissues

MY Lin, YL Wang, WL Wu, V Wolseley, MT Tsai… - Scientific reports, 2017 - nature.com
Zika virus (ZIKV) infection is associated with microcephaly in fetuses, but the pathogenesis
of ZIKV-related microcephaly is not well understood. Here we show that ZIKV infects the …

Zika infection disrupts proteins involved in the neurosensory system

KKM Glover, A Zahedi-Amiri, Y Lao, V Spicer… - Frontiers in Cell and …, 2020 - frontiersin.org
Newly re-emerging viruses are of great global concern, especially when there are no
therapeutic interventions available during the time of an outbreak. There are still no …

Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors

L Liu, Z Chen, X Zhang, S Li, Y Hui, H Feng… - Cell Death & …, 2019 - nature.com
It remains largely unknown how Zika virus (ZIKV) infection causes severe microcephaly in
human newborns. We examined an Asian lineage ZIKV, SZ01, which similarly infected and …

[HTML][HTML] Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3

J Dang, SK Tiwari, G Lichinchi, Y Qin, VS Patil… - Cell stem cell, 2016 - cell.com
Emerging evidence from the current outbreak of Zika virus (ZIKV) indicates a strong causal
link between Zika and microcephaly. To investigate how ZIKV infection leads to …

Zika virus-mediated death of hippocampal neurons is independent from maturation state

C Büttner, M Heer, J Traichel, M Schwemmle… - Frontiers in Cellular …, 2019 - frontiersin.org
Zika virus (ZIKV) infection of pregnant women and diaplazental transmission to the fetus is
linked to the congenital syndrome of microcephaly in newborns. This neuropathology is …

Zika virus infects human fetal brain microglia and induces inflammation

FM Lum, DKS Low, Y Fan, JJL Tan… - Clinical Infectious …, 2017 - academic.oup.com
Background. The unprecedented reemergence of Zika virus (ZIKV) has startled the world
with reports of increased microcephaly in Brazil. ZIKV can infect human neural progenitors …

Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

PF Ledur, K Karmirian, CSG Pedrosa, LRQ Souza… - Scientific reports, 2020 - nature.com
Zika virus (ZIKV) has been extensively studied since it was linked to congenital
malformations, and recent research has revealed that astrocytes are targets of ZIKV …

Zika infection and the development of neurological defects

FB Russo, P Jungmann… - Cellular …, 2017 - Wiley Online Library
Starting with the outbreak in Brazil, Zika virus (ZIKV) infection has been correlated with
severe syndromes such as congenital Zika syndrome and Guillain‐Barré syndrome. Here …

Clinical and preclinical evidence for adverse neurodevelopment after postnatal Zika virus infection

J Raper, A Chahroudi - Tropical Medicine and Infectious Disease, 2021 - mdpi.com
Although the Zika virus (ZIKV) typically causes mild or no symptoms in adults, during the
2015− 2016 outbreak, ZIKV infection in pregnancy resulted in a spectrum of diseases in …

Zika virus infection leads to demyelination and axonal injury in mature CNS cultures

V Schultz, SL Cumberworth, Q Gu, N Johnson… - Viruses, 2021 - mdpi.com
Understanding how Zika virus (Flaviviridae; ZIKV) affects neural cells is paramount in
comprehending pathologies associated with infection. Whilst the effects of ZIKV in neural …