Pancreatic p-cells are strongly engagedin protein secretion and have highly developed
endoplasmic reticulum (ER). Proper folding of polypeptide into a threedimensional structure …

Endoplasmic reticulum (ER) stress is an integral part of life for all professional secretory
cells, but it has been studied to greatest depth in the pancreatic β‐cell. This reflects both the …

The endoplasmic reticulum (ER) is a cellular compartment responsible for multiple important
cellular functions including the biosynthesis and folding of newly synthesized proteins …

In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment
for insulin biosynthesis, which accounts for half of the total protein production in these cells …

The pancreatic β-cell senses nutrients, neurotransmitters and hormones in the circulating
blood. The unique function of the cell is to integrate all these ambient signals into an …

Overwhelming of protein folding in the endoplasmic reticulum (ER)—referred to as “ER
stress”—activates a set of intracellular signaling pathways termed the unfolded protein …

Background Cells respond to endoplasmic reticulum stress (ER) stress by activating the
unfolded protein response. To study the ER stress response in pancreatic β-cells we …

Insulin resistance and pancreatic beta cell dysfunction are major contributors to the
pathogenesis of diabetes. Various conditions play a role in the pathogenesis of pancreatic …

Eukaryotic cells respond to stress in the endoplasmic reticulum (ER) resulting from
insufficient protein folding capacity or altered ER homeostasis by activating the unfolded …

The endoplasmic reticulum (ER) is a central organelle entrusted with lipid synthesis, protein
folding and protein maturation. It is endowed with a quality control system that facilitates the …