Background Genetic susceptibility may play a more important role in the etiology of early-
onset inflammatory bowel disease (IBD) than in late-onset IBD, and therefore pediatric-onset …

Aim To investigate the association between known inflammatory bowel disease (IBD)-
associated genetic variants and development of paediatric IBD, and specific clinical sub …

Inflammatory Bowel disease (IBD) is a widespread pathological condition with clinical
heterogeneity and with different levels of severity. Although IBD usually occurs in young …

Background Despite a large body of literature on the subject of Crohn's disease (CD), very
little information is available on racial/ethnic differences related to disease presentation …

Background Early-onset disease is frequently examined in genetic studies because it is
presumed to contain a more severe subset of patients under a higher influence of genetic …

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD), ulcerative colitis
(UC), and unclassified IBD, is characterized by chronic intestinal inflammation and has a …

AIM: To assess whether the polymorphisms of NOD2/CARD15, autophagy-related 16-like 1
(ATG16L1), and interleukin-23 receptor (IL23R) genes play a more critical role in the …

Background & aims Disease outcome has been found to be poorer in familial inflammatory
bowel disease (IBD) than in sporadic forms, but assessment of phenotypic concordance in …

Introduction The incidence of early-onset CD in Scotland is among the highest worldwide.
Three single nucleotide polymorphisms (SNPs) R702W, G908R and Leu1007finsC in the …

Background & Aims Recent studies reported a role for more than 70 genes or loci in the
susceptibility to Crohn's disease (CD). However, the impact of these associations in clinical …