The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-
inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation …

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway regulates
cell proliferation, differentiation, and migration, along with angiogenesis and metabolism …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

PhosphoInositide-3 Kinase (PI3K) represents a family of different classes of kinases which
control multiple biological processes in mammalian cells, such as cell growth, proliferation …

The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …

The mammalian target of rapamycin (mTOR) and the phosphoinositide 3-kinase (PI3K)
signaling pathways are commonly deregulated in cancers and promote cellular growth …

The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in
the regulation of cell proliferation, survival, and motility in response to availability of energy …

Abstract The PI3K/Akt/mTOR pathway is the most frequently known activated aberrant
pathway in human cancers. Pathologic activation can occur at multiple levels along the …

The phosphatidylinositol 3 kinase (PI3K) pathway is one of the major pathways modulating
cell growth, proliferation, metabolism, survival, and angiogenesis. Hyperactivation of this …