MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology,
and we previously reported that inhibition of miR-34a in vivo provided protection in a setting …

MicroRNAs are dysregulated in a setting of heart disease and have emerged as promising
therapeutic targets. MicroRNA-34 family members (miR-34a,-34b, and-34c) are up …

Rationale Myocardial infarction (MI) triggers a dynamic microRNA response with the
potential of yielding therapeutic targets. Objective We aimed to identify novel aberrantly …

MicroRNA-21 (miR-21) plays a significant role in the regulation of fibrotic and inflammatory
gene expression signatures. Endogenous miR-21 shows robust expression in different types …

Non-ischemic diabetic heart disease (NiDHD) is characterized by diastolic dysfunction and
decreased or preserved systolic function, eventually resulting in heart failure. Accelerated …

MicroRNAs (miRNAs) control the expression of diverse subsets of target mRNAs, and
studies have found miRNA dysregulation in failing hearts. Expression of miR-29 is abundant …

Therapeutic inhibition of the miR-34 family (miR-34a,-b,-c), or miR-34a alone, have emerged
as promising strategies for the treatment of cardiac pathology. However, before advancing …

Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The
microRNA-29 (miR-29) family has been found to prevent excess collagen expression in …

MicroRNAs inhibit mRNA translation or promote mRNA degradation by binding
complementary sequences in 3′ untranslated regions of target mRNAs. MicroRNA-21 (miR …

Rationale: The adult heart is composed primarily of terminally differentiated, mature
cardiomyocytes that express signature genes related to contraction. In response to …