In principle, the formation of the 3 end of a eukaryotic mRNA is a simple process. At a
minimum, it involves the hydrolysis of a single phosphodiester bond in the nascent …

Many components of the mammalian and yeast pre-mRNA 3′-end-processing machinery
have recently been purified and cDNAs or genes coding for these factors have been cloned …

This volume focuses on the major aspects of post-transcriptional mRNA processing in the
nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper …

ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …

Nearly all eukaryotic mRNAs end with a poly (A) tail that is added to their 3′ end by the
ubiquitous cleavage/polyadenylation machinery. The only known exceptions to this rule are …

The 3′‐ends of almost all eukaryotic mRNAs are formed in a two‐step process, an
endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or …

he past fifteen years have seen tremendous growth in our understanding of T the many post-
transcriptional processing steps involved in producing func tional eukaryotic mRNA from …

Pre-mRNA 3′ end formation is an essential step in eukaryotic gene expression. Over half of
human genes produce alternatively polyadenylated mRNAs, suggesting that regulated …

The replication-dependent histone mRNAs in metazoa are not polyadenylated, in contrast to
the bulk of mRNA. Instead, they contain an RNA stem–loop (SL) structure close to the 3 …

Pre‐mRNAs are typically processed at the 3′ end by cleavage/polyadenylation. This is a
two‐step processing reaction initiated by endonucleolytic cleavage of pre‐mRNAs …