Genome-wide placental gene methylations in gestational diabetes mellitus, fetal growth and metabolic health biomarkers in cord blood

WJ Wang, R Huang, T Zheng, Q Du, MN Yang… - Frontiers in …, 2022 - frontiersin.org
Gestational diabetes mellitus (GDM)“program” an elevated risk of metabolic syndrome in the
offspring. Epigenetic alterations are a suspected mechanism. GDM has been associated …

DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring

S Lu, J Wang, N Kakongoma, W Hua, J Xu, Y Wang… - Clinical …, 2022 - Springer
Background Gestational diabetes mellitus (GDM) is a common pregnancy-specific disease
and is growing at an alarming rate worldwide, which can negatively affect the health of …

Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring

S Finer, C Mathews, R Lowe, M Smart… - Human molecular …, 2015 - academic.oup.com
Exposure of a developing foetus to maternal gestational diabetes (GDM) has been shown to
programme future risk of diabetes and obesity. Epigenetic variation in foetal tissue may have …

DNA methylation profiles in placenta and its association with gestational diabetes mellitus

C Rong, X Cui, J Chen, Y Qian, R Jia… - … Clinical Endocrinology & …, 2015 - thieme-connect.com
Emerging evidences indicate that placenta plays a critical role in gestational diabetes
mellitus (GDM). DNA methylation could be associated with altered placental development …

Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy

J Alexander, AM Teague, J Chen, CE Aston, YK Leung… - PloS one, 2018 - journals.plos.org
Aims/Hypothesis We hypothesized that diabetes during pregnancy (DDP) alters genome-
wide DNA methylation in placenta resulting in differentially methylated loci of metabolically …

Genome-wide DNA methylation variation in maternal and cord blood of gestational diabetes population

J Kang, CN Lee, HY Li, KH Hsu, SY Lin - Diabetes research and clinical …, 2017 - Elsevier
Aims Gestational diabetes mellitus (GDM) has always been a concerning issue for pregnant
women. In recent studies, GDM was found to be related to epigenetic modifications, which …

Epigenome-wide association study reveals methylation loci associated with offspring gestational diabetes mellitus exposure and maternal methylome

M Canouil, A Khamis, E Keikkala, S Hummel… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE Gestational diabetes mellitus (GDM) is associated with an increased risk of
obesity and insulin resistance in offspring later in life, which might be explained by …

Genome-wide DNA methylation profiling in infants born to gestational diabetes mellitus

X Weng, F Liu, H Zhang, M Kan, T Wang… - Diabetes Research and …, 2018 - Elsevier
Background Offspring exposed to gestational diabetes mellitus (GDM) are at a high risk for
metabolic diseases. The mechanisms behind the association between offspring exposed to …

Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases

SM Ruchat, AA Houde, G Voisin, J St-Pierre… - Epigenetics, 2013 - Taylor & Francis
Offspring exposed to gestational diabetes mellitus (GDM) have an increased risk for chronic
diseases, and one promising mechanism for fetal metabolic programming is epigenetics …

Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors

MN Yang, R Huang, T Zheng, Y Dong, WJ Wang… - Clinical …, 2022 - Springer
Background Fetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood.
Epigenetic alterations may be a mechanism in programming the vulnerability. We sought to …