Contradictory effects of ovarian hormone on cocaine-induced behaviors have been reported
in ovariectomized Fischer rats [1, 2]. To determine if these discrepancies are based on …

There are significant gender differences in course, symptomology, and treatment of
substance use disorders. In general data from clinical and preclinical studies of substance …

Previous findings in our laboratory and elsewhere have shown that ovariectomy of rats in
adulthood attenuates cocaine‐stimulated locomotor behaviour. Ovarian hormones enhance …

While acute and chronic d-amphetamine (AMPH) treatments produce greater scores for
locomotor activity in female rats in comparison with male rats, little is known about AMPH …

Female sexual behavior is an established model of a naturally motivated behavior which is
regulated by activity within the mesolimbic dopamine system. Repeated activation of the …

Estradiol moderates the effects of drugs of abuse in both humans and rodents. Estradiol's
enhancement of behavioral effects resulting from high (> 2.5 mg/kg) doses of amphetamine …

Hormonal contraceptives (HCs), prescribed to millions of women around the world, alter the
ovarian hormonal cycle resulting in neurobehavioral changes in HC users. Human …

Estradiol potentiates behavioral sensitization to cocaine as well as self-administration of
cocaine and other drugs of abuse in female rodents. Furthermore, stimulated dopamine (DA) …

Rationale: Little is known about the interactions between ovarian hormones across the
menstrual cycle and responses to psychoactive drugs in humans. Preclinical studies …

When ovariectomized female rats receive estrogen, the response to the psychomotor
stimulants amphetamine or cocaine is enhanced. Estrous cycle‐dependent differences in …