Pathogenic inflammation and its therapeutic targeting in systemic lupus erythematosus

TA Gottschalk, E Tsantikos, ML Hibbs - Frontiers in immunology, 2015 - frontiersin.org
Systemic lupus erythematosus (SLE, lupus) is a highly complex and heterogeneous
autoimmune disease that most often afflicts women in their child-bearing years. It is …

Systemic lupus erythematosus (SLE): emerging therapeutic targets

LM Mathias, W Stohl - Expert Opinion on Therapeutic Targets, 2020 - Taylor & Francis
Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a
heterogeneous clinical presentation whose etiologies are multifactorial. A myriad of genetic …

Pragmatic approaches to therapy for systemic lupus erythematosus

W Xiong, RG Lahita - Nature Reviews Rheumatology, 2014 - nature.com
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with substantial
clinical heterogeneity. Current treatments for SLE are effective at reducing morbidity and …

Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy

MS Lo, GC Tsokos - Current opinion in rheumatology, 2018 - journals.lww.com
Recent developments in systemic lupus erythematosus pathogen... : Current Opinion in
Rheumatology Recent developments in systemic lupus erythematosus pathogenesis and …

The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosus

LS Davis, J Hutcheson, C Mohan - Journal of interferon & cytokine …, 2011 - liebertpub.com
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized
by a defect in immune tolerance and exacerbated by both the innate and adaptive arms of …

New insights into the immunopathogenesis of systemic lupus erythematosus

GC Tsokos, MS Lo, PC Reis, KE Sullivan - Nature Reviews …, 2016 - nature.com
The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

New directions in the treatment of systemic lupus erythematosus

K Kalunian, TM Joan - Current medical research and opinion, 2009 - Taylor & Francis
Objective: The aim of this review is to provide an up-to-date overview of treatment
approaches for systemic lupus erythematosus (SLE), highlighting the multiplicity and …

The pathogenesis of systemic lupus erythematosus—an update

J Choi, ST Kim, J Craft - Current opinion in immunology, 2012 - Elsevier
Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-
tolerance with activation of autoreactive T and B cells leading to production of pathogenic …

[HTML][HTML] Recent advances in the management of systemic lupus erythematosus

S Sciascia, M Radin, D Roccatello, G Sanna… - …, 2018 - ncbi.nlm.nih.gov
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease presenting highly
heterogeneous clinical manifestations and multi-systemic involvement. Patients are …

Current and novel therapeutics in the treatment of systemic lupus erythematosus

C Yildirim-Toruner, B Diamond - Journal of Allergy and Clinical …, 2011 - Elsevier
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant
clinical heterogeneity. Recent advances in our understanding of the genetic, molecular, and …