Molecular mechanism of estrogen receptor (ER) α-specific, estradiol-dependent expression of the progesterone receptor (PR) B-isoform

T Flötotto, D Niederacher, D Hohmann… - The Journal of steroid …, 2004 - Elsevier
The physiological effects of progesterone are mediated by the progesterone receptor (PR)
isoforms PRA and PRB, transcribed from a single gene, under control of two distinct …

Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody

DL Clemm, L Sherman… - Molecular …, 2000 - academic.oup.com
Human progesterone receptor (PR) is phosphorylated on multiple serine residues (at least
seven sites) in a manner that involves distinct groups of sites coordinately regulated by …

Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression

KM Scarpin, JD Graham, PA Mote… - Nuclear receptor …, 2009 - journals.sagepub.com
Progesterone is a critical regulator of normal female reproductive function, with diverse
tissue-specific effects in the human. The effects of progesterone are mediated by its nuclear …

Progesterone and the progesterone receptor.

P Bouchard - The Journal of Reproductive Medicine, 1999 - europepmc.org
During the 1990s, extensive research has effectively mapped the progesterone receptor-
mediated actions of progesterone and has more recently uncovered nonreceptor-mediated …

[PDF][PDF] Reproductive functions of progesterone receptors

OM Conneely, B Mulac-Jericevic, F DeMayo… - Recent progress in …, 2002 - endocrine.org
The steroid hormone progesterone plays a central role in the reproductive events associated
with pregnancy establishment and maintenance. Physiological effects of progesterone are …

Characterization of transiently and constitutively expressed progesterone receptors: evidence for two functional states

CL Smith, RG Wolford, TB O'Neill… - Molecular …, 2000 - academic.oup.com
Activated steroid receptors induce chromatin remodeling events in the promoters of some
target genes. We previously reported that transiently expressed progesterone receptor (PR) …

An N-terminally truncated third progesterone receptor protein, PRC, forms heterodimers with PRB but interferes in PRB-DNA binding

LL Wei, BM Norris, CJ Baker - The Journal of steroid biochemistry and …, 1997 - Elsevier
Multiple progesterone receptor (PR) isoforms may explain in part the complex and diverse
biological actions of progestins. Recent studies demonstrate that the human 116 kDa B …

Expression and localization of the progesterone receptor in mouse and human reproductive organs

SC Teilmann, CA Clement, J Thorup… - Journal of …, 2006 - joe.bioscientifica.com
The effects of gonadotropins on progesterone receptor (PR) expression and localization in
the mouse oviduct, uterus, and ovary was examined. In the oviduct ciliated epithelial cells of …

Expression of progesterone receptor isoforms in corpora lutea of human subjects: correlation with serum oestrogen and progesterone concentrations.

R Misao, Y Nakanishi, S Iwagaki… - Molecular human …, 1998 - academic.oup.com
To understand the biological significance of progesterone receptor forms A (PR-A) and B
(PR-B) in human corpus luteum, the expression of mRNA and serum steroid hormone …

Cloning and expression of a novel, truncated, progesterone receptor

KJ Saner, BH Welter, F Zhang, E Hansen… - Molecular and cellular …, 2003 - Elsevier
Progesterone acts via two specific receptors to affect gene transcription in target tissues.
Progesterone receptor (PR) B contains 933 amino acids while PR A is a truncated version …