Azepane-based compounds showed a variety of pharmacological properties, and its
derivatives possess a high degree of structural diversity, and it is useful for the discovery of …

Azapeptides are peptide analogs in which one or more of the amino residues is replaced by
a semicarbazide. This substitution of a nitrogen for the α-carbon center results in …

Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …

Functionalised azepane and oxepane scaffolds were prepared using diazocarbonyl
chemistry and elaborated to show their potential use in library synthesis. Key dicarbonyl …

The ubiquity of strained motifs in drug discovery has recently witnessed a large regain of
interest, as such scaffold can be used to modulate the properties of drug candidates …

Imines are multipurpose pharmacophores, simply accessible compounds, and have a broad
range of usage in several areas of chemistry especially in medicine. Two novel compound …

Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …

Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds.
Azetidine scaffold has been discovered in several natural products. Several …

The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …

Anthranilic acid and its analogues present a privileged profile as pharmacophores for the
rational development of pharmaceuticals deliberated for managing the pathophysiology and …