Little is known about the polarizing potential of currently used human macrophage cell lines,
while a better understanding phenomena can support the prediction of effects in vivo based …

Macrophages derived from human monocytic leukemia THP-1 cell line are often used as the
alternative of human primary macrophage. However, the polarization method of THP-1 to …

Macrophages (Mφ) undergo activation to pro-inflammatory (M1) or anti-inflammatory (M2)
phenotypes in response to pathophysiologic stimuli and dysregulation of the M1-M2 balance …

BACKGROUND: Polarization of macrophages by specific micro-environmental conditions
impacts upon their function following subsequent activation. This study aimed to …

Macrophages are highly plastic cells that can polarize into functionally distinct subsets in
vivo and in vitro in response to environmental signals. The development of protocols to …

Human peripheral-blood monocytes are used as an established in vitro system for
generating macrophages. For several reasons, monocytic cell lines such as THP-1 have …

Macrophages are versatile cells of the immune system which react to various external stimuli
through different polarization patterns which adjust the cells to the required function whether …

Macrophages are key in orchestrating immune responses to micro-environmental stimuli,
sensed by a complex set of surface receptors. The human cell line THP-1 has a monocytic …

Macrophages are a heterogeneous population of innate myeloid cells involved in health and
disease, which are the most functionally diverse cells of the hematopoietic system. The main …

Macrophages as innate immune cells with great plasticity are of great interest for cell
therapy. There are two main macrophage populations–pro-and anti-inflammatory cells also …