Targeted inactivation of Dp71, the major non-muscle product of the DMD gene: differential activity of the Dp71 promoter during development

R Sarig, V Mezger-Lallemand, I Gitelman… - Human Molecular …, 1999 - academic.oup.com
The dystrophin gene, which is defective in Duchenne muscular dystrophy (DMD), also
encodes a number of smaller products controlled by internal promoters. Dp71, which …

Differential expression and subcellular distribution of dystrophin Dp71 isoforms during differentiation process

FG Marquez, B Cisneros, F Garcia, V Ceja… - Neuroscience, 2003 - Elsevier
Dp71 is the major product of the Duchenne muscular dystrophy gene in the brain. In order to
study the function of Dp71 in the nervous system we examined the expression of Dp71 …

Dystrophin Dp71 expression is down-regulated during myogenesis: role of Sp1 and Sp3 on the Dp71 promoter activity

MB De León, C Montanez, P Gómez… - Journal of Biological …, 2005 - ASBMB
Dp71 expression is present in myoblasts but declines during myogenesis to avoid interfering
with the function of dystrophin, the predominant Duchenne muscular dystrophy gene product …

Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71

DS Greenberg, Y Schatz, Z Levy, P Pizzo… - Human molecular …, 1996 - academic.oup.com
Duchenne muscular dystrophy (DMD) is a progressive degenerative lethal muscle disease.
A significant proportion of DMD affected children suffer also from mental retardation. The rod …

Cloning and characterization of alternatively spliced isoforms of Dp71

A Richard C, PL Howard, VN D'Souza… - Human molecular …, 1995 - academic.oup.com
Dp71, a C-terminal isoform of dystrophin, has been identified as the major DMD gene
product in many nonmuscle tissues. In this report, reverse transcriptase-polymerase chain …

A housekeeping type promoter, located in the 3'region of the Duchenne muscular dystrophy gene, controls the expression of Dp71, a major product of the gene

D Lederfein, D Yaffe, U Nudel - Human molecular genetics, 1993 - academic.oup.com
The 70.8 kDa protein product of the distal part of the giant Duchenne muscular dystrophy
(DMD) gene, Dp71, is expressed in many cell types and tissues. Anchored PCR, primer …

Exogenous Dp71 restores the levels of dystrophin associated proteins but does not alleviate muscle damage in mdx mice

DS Greenberg, Y Sunada, KP Campbell, D Yaffe… - Nature …, 1994 - nature.com
Dp71 is a non-muscle product of the Duchenne muscular dystrophy gene. It consists of the
cysteine-rich and C-terminal domains of dystrophin. We have generated transgenic mdx …

Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting

CN Lumeng, M Hauser, V Brown, JS Chamberlain - Brain research, 1999 - Elsevier
To investigate the function of the major non-muscle dystrophin isoform, Dp71, we substituted
a β-galactosidase (βgal) reporter gene for Dp71 by homologous recombination in embryonic …

Subcellular localization of Dp71 dystrophin isoforms in cultured hippocampal neurons and forebrain astrocytes

V Aleman, B Osorio, O Chavez, A Rendon… - Histochemistry and cell …, 2001 - Springer
It has been suggested that the absence or altered structure of Dp71, a C-terminal dystrophin
gene encoded protein, is responsible for mental alterations observed in about 30% of …

Targeted disruption of exon 52 in the mouse dystrophin gene induced muscle degeneration similar to that observed in Duchenne muscular dystrophy

E Araki, K Nakamura, K Nakao, S Kameya… - Biochemical and …, 1997 - Elsevier
Duchenne muscular dystrophy (DMD) is a degenerative disorder of the skeletal muscle in
human and is caused by mutations in the dystrophin gene. Themdxmouse is a spontaneous …