Experiments were performed to identify arginase isoforms expressed in primary and
transformed rodent macrophages and to determine the molecular mechanisms for the …

Macrophages can express two arginase isoforms with distinct subcellular localization
(cytosolic AI and mitochondrial AII). These isoforms are products of different genes and are …

Arginase exists in two isoforms, the hepatic (arginase I) and extrahepatic types (arginase II).
Arginase I is markedly induced in rat peritoneal macrophages and rat tissues in vivo by …

Activated macrophages avidly consume arginine via the action of inducible nitric oxide
synthase (iNOS) and/or arginase. In contrast to our knowledge regarding macrophage iNOS …

Previous studies have shown high arginase activity at inflammatory sites. Arginase convertsl-
arginine tol-ornithine, sharing a common substrate with nitric oxide synthase. It exists as two …

Arginase exists in two isoforms. Liver-type arginase (arginase I) is expressed almost
exclusively in the liver and catalyzes the last step of urea synthesis, whereas the nonhepatic …

The balance of arginine metabolism via nitric oxide synthase (NOS) or arginase is an
important determinant of the inflammatory response of murine macrophages and dendritic …

Activated murine macrophages metabolize arginine by two alternative pathways involving
the enzymes inducible NO synthase (iNOS) or arginase. The balance between the two …

Nitric oxide is synthesized by nitric-oxide synthase from arginine, a common substrate of
arginase. Rat peritoneal macrophages were cultured in the presence of bacterial …

Arginase shares a common substrate, l-arginine, with nitric oxide synthase (NOS). Both
enzymes are active at inflammatory sites. To understand regulation of arginase and its …