The discovery of superoxide dis-mutase by McCord and Fridov-ich (1) ushered in a new
area of biology wherein free radicals had to be factored into the biology of animals and …

Over the past 5 years there has been an explosion of new information on the physiological
and pathophysiological roles of NO within the heart as in other organ systems. In this review …

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and
regulates cardiac function through both vascular-dependent and-independent effects. The …

Emerging evidence supports the importance of nitroso-redox balance in the cardiovascular
system. Xanthine oxidoreductase (XOR) is a major oxidative enzyme and increased XOR …

Although interactions between superoxide () and nitric oxide underlie many physiologic and
pathophysiologic processes, regulation of this crosstalk at the enzymatic level is poorly …

The roles of nitric oxide (NO) in the heart have been studied intensely ever since the first
report nearly 2 decades ago showing that endogenous NO modulates cardiac myocyte …

NOS: Modulator, not mediator of cardiac performance | Nature Medicine Skip to main content
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Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …

Figure. Effect of xanthine oxidase (XO) inhibition (XOI) on the nitroso-redox balance. The
underlying mechanistic basis for the use of XOIs in the failing heart. As shown, XOIs act on a …

The free radical gas nitric oxide (NO) is produced by 3 isoforms of nitric oxide synthase
(NOS). All of them are present in the heart: NOS1 (nNOS,“neuronal” NOS) has been …