Background—Evidence indicates that myocardial NO production can modulate contractility,
but the source of NO remains uncertain. Here, we investigated the role of a type 1 NO …

In the heart, nitric oxide (NO) is constitutively produced by the vascular and endocardial
endothelium, the cardiomyocytes and the autonomic nerves. Whereas stimulation of NO …

Nitric oxide (NO) acts as an autocrine-and paracrine-acting signaling autacoid that, among
other functions, has been shown to regulate cardiac contractile responsiveness to beta …

Subcellular localization of nitric oxide (NO) synthases with effector molecules is an important
regulatory mechanism for NO signalling. In the heart, NO inhibits L-type Ca2+ channels but …

The nitric oxide (NO•) sibling, nitroxyl or nitrosyl hydride (HNO), is emerging as a molecule
whose pharmacological properties include providing functional support to failing hearts …

Nitric oxide (NO), produced by either constitutive or inducible isoforms of NO synthase
(cNOS or iNOS), influences myocardial inotropic and chronotropic responses. This pathway …

Recognition of significance of nitric oxide synthases (NOS) in cardiovascular regulations has
led to intensive research and development of therapies focused on NOS as potential …

Nitric oxide (NO) is one of the most remarkable biological molecules characterized at the
turn of XX century. Small in size, but ubiquitous and complex in its network of molecular …

The seminal observation by Furchgott and Zawadzki [1] of a paradoxical vasoconstrictive
effect of acetylcholine in arteries deprived of endothelium paved the way for the rapid …

Cardiac excitation–contraction coupling and metabolic and signaling activities are centrally
modulated by nitric oxide (NO), which is produced by one of three NO synthases (NOSs) …