ABSTRACT Introduction: Wingless-type (Wnt) signaling is tightly regulated at multiple
cellular levels and is dysregulated in lung cancer. Therefore, it offers therapeutic targets for …

Non-small cell lung cancer (NSCLC) is the malignant tumor with the highest morbidity and
leading cause of death worldwide, whereas its pathogenesis has not been fully elucidated …

The Wnt pathway plays an important role in development and in regulating adult stem cell
systems. A variety of cellular processes is mediated by Wnt signaling, which includes …

Wnt signal is known to play a significant role in many cellular processes such as cell
proliferation, survival, self-renewal, and differentiation. This pathway has been linked to …

Wnt signaling has recently emerged as a critical pathway in lung carcinogenesis as already
demonstrated in many cancers and particularly in colorectal cancer. We critically discuss in …

Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the
complex roles for WNT signaling pathways in lung cancers has increased substantially. In …

The WNT family of signaling proteins is essential to organ development in general and lung
morphogenesis in particular. Originally identified as a developmentally active signaling …

Significant advances in the treatment of non-small cell lung cancer (NSCLC) have been
made over the past decade, and they predominantly involve molecular targets such as …

The Wnt/β-catenin pathway is abnormally activated in most lung cancer tissues and
considered to be an accelerator of carcinogenesis and lung cancer progression, which is …

Wnt/β-catenin alterations are prominent in human malignancies. In non–small cell lung
cancer (NSCLC), β-catenin and APC mutations are uncommon, but Wnt signaling is …