Higher intratumoral expression of CD1a, tryptase, and CD68 in a follicular variant of papillary thyroid carcinoma compared to adenomas: correlation with clinical and …

A Proietti, C Ugolini, RM Melillo, G Crisman, R Elisei… - Thyroid, 2011 - liebertpub.com
Background: In a number of human malignancies, the presence of lymphocytic infiltration in
or around tumor tissue is commonly considered to be part of the host tumor immune …

The role of the inflammatory microenvironment in thyroid carcinogenesis

LL Cunha, MA Marcello, LS Ward - Endocr Relat Cancer, 2014 - erc.bioscientifica.com
Immune responses against thyroid carcinomas have long been demonstrated and
associations between inflammatory microenvironment and thyroid carcinomas repeatedly …

Single-cell RNA sequencing revealed a 3-gene panel predicted the diagnosis and prognosis of thyroid papillary carcinoma and associated with tumor immune …

Z Chen, Y Wang, D Li, Y Le, Y Han, L Jia, C Yan… - Frontiers in …, 2022 - frontiersin.org
Objective: Screening prognostic related genes of thyroid papillary carcinoma (PTC) by
single-cell RNA sequencing (scRNA-seq). To construct the diagnostic and prognostic …

A new risk factor indicator for papillary thyroid cancer based on immune infiltration

Z Yang, X Wei, Y Pan, J Xu, Y Si, Z Min, B Yu - Cell death & disease, 2021 - nature.com
Increasing evidence has indicated a close association between immune infiltration in cancer
and clinical outcomes. However, related research in thyroid cancer is still deficient. Our …

A novel gene panel for prediction of lymph-node metastasis and recurrence in patients with thyroid cancer

EML Ruiz, T Niu, M Zerfaoui, M Kunnimalaiyaan… - Surgery, 2020 - Elsevier
Background Although well-differentiated papillary thyroid cancer may remain indolent,
lymph node metastases and the recurrence rates are approximately 50% and 20 …

The genomic landscape of thyroid cancer tumourigenesis and implications for immunotherapy

A Singh, J Ham, JW Po, N Niles, T Roberts, CS Lee - Cells, 2021 - mdpi.com
Thyroid cancer is the most prevalent endocrine malignancy that comprises mostly indolent
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …

Immune profiling of advanced thyroid cancers using fluorescent multiplex immunohistochemistry

J Ahn, M Jin, E Song, Y Ryu, DE Song, SY Kim, TY Kim… - Thyroid, 2021 - liebertpub.com
Background: Advanced thyroid cancers, including differentiated thyroid carcinoma (DTC)
with distant metastasis, and anaplastic thyroid carcinoma (ATC), are associated with poor …

Prognostic subtypes of thyroid cancer was constructed based on single cell and bulk-RNA sequencing data and verified its authenticity

F Yang, Y Yu, H Zhou, Y Zhou - Functional & Integrative Genomics, 2023 - Springer
There has been an increase in the mortality rate of thyroid cancer (THCA), which is the most
common endocrine malignancy. We identified six distinct cell types in the THAC …

CD 8+ tumour‐infiltrating lymphocytes and COX2 expression may predict relapse in differentiated thyroid cancer

LL Cunha, MA Marcello, S Nonogaki… - Clinical …, 2015 - Wiley Online Library
Background/objective There is an increasing rate of papillary thyroid carcinomas that may
never progress to cause symptoms or death. Predicting outcome and determining tumour …

Immune gene signature delineates a subclass of papillary thyroid cancer with unfavorable clinical outcomes

K Kim, S Jeon, TM Kim, CK Jung - Cancers, 2018 - mdpi.com
Papillary thyroid carcinoma (PTC) represents a heterogeneous disease with diverse clinical
outcomes highlighting a need to identify robust biomarkers with clinical relevance. We …