Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model

RD Hoge, J Atkinson, B Gill, GR Crelier… - … in Medicine: An …, 1999 - Wiley Online Library
The relationship between blood oxygenation level‐dependent (BOLD) MRI signals, cerebral
blood flow (CBF), and oxygen consumption (CMRO2) in the physiological steady state was …

Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRI

K Uludağ, DJ Dubowitz, EJ Yoder, K Restom, TT Liu… - Neuroimage, 2004 - Elsevier
The physiological basis of the blood oxygenation level dependent (BOLD) signal and its
dependence on baseline cerebral blood flow (CBF) were investigated by comparing …

A generalized procedure for calibrated MRI incorporating hyperoxia and hypercapnia

CJ Gauthier, RD Hoge - Human brain mapping, 2013 - Wiley Online Library
Calibrated MRI techniques use the changes in cerebral blood flow (CBF) and blood
oxygenation level‐dependent (BOLD) signal evoked by a respiratory manipulation to …

Quantitative BOLD: mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: default state

X He, DA Yablonskiy - … in Medicine: An Official Journal of the …, 2007 - Wiley Online Library
Since Ogawa et al.(Proc Natl Acad Sci USA 1990; 87: 9868–9872) made the fundamental
discovery of blood oxygenation leveldependent (BOLD) contrast in MRI, most efforts have …

High-Resolution CMRO2 Mapping in Rat Cortex: A Multiparametric Approach to Calibration of BOLD Image Contrast at 7 Tesla

I Kida, RP Kennan, DL Rothman… - Journal of Cerebral …, 2000 - journals.sagepub.com
The blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging
(fMRI) method, which is sensitive to vascular paramagnetic deoxyhemoglobin, is dependent …

Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia

RG Wise, AD Harris, AJ Stone, K Murphy - Neuroimage, 2013 - Elsevier
Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …

Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF

AL Lin, PT Fox, Y Yang, H Lu, LH Tan… - … in Medicine: An …, 2008 - Wiley Online Library
The aim of this study was to investigate the various MRI biophysical models in the
measurements of local cerebral metabolic rate of oxygen (CMRO2) and the corresponding …

Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: implications for BOLD-fMRI

BM Ances, O Leontiev, JE Perthen, C Liang… - Neuroimage, 2008 - Elsevier
Functional magnetic resonance imaging (fMRI) based on blood oxygenation level
dependent (BOLD) signal changes is a sensitive tool for mapping brain activation, but …

BOLD‐specific cerebral blood volume and blood flow changes during neuronal activation in humans

JJ Chen, GB Pike - … : An International Journal Devoted to the …, 2009 - Wiley Online Library
To understand and predict the blood‐oxygenation level‐dependent (BOLD) fMRI signal, an
accurate knowledge of the relationship between cerebral blood flow (ΔCBF) and volume …

Determination of relative CMRO2 from CBF and BOLD changes: Significant increase of oxygen consumption rate during visual stimulation

SG Kim, E Rostrup, HBW Larsson… - … in Medicine: An …, 1999 - Wiley Online Library
The blood oxygenation level‐dependent (BOLD) effect in functional magnetic resonance
imaging depends on at least partial uncoupling between cerebral blood flow (CBF) and …