Identification of Natural Compound Inhibitors for Multidrug Efflux Pumps of Escherichia coli and Pseudomonas aeruginosa Using In Silico High-Throughput Virtual Screening …
V Aparna, K Dineshkumar, N Mohanalakshmi… - PloS one, 2014 - journals.plos.org
Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics
rendering the treatment of infections very difficult. A main mechanism attributed to the …
rendering the treatment of infections very difficult. A main mechanism attributed to the …
In vitro and in silico evidences about the inhibition of MepA efflux pump by coumarin derivatives
ALAR Martin, RLS Pereira, JE Rocha, PAM Farias… - Microbial …, 2023 - Elsevier
The discovery of antibiotics has significantly transformed the outcomes of bacterial infections
in the last decades. However, the development of antibiotic resistance mechanisms has …
in the last decades. However, the development of antibiotic resistance mechanisms has …
Microbial Efflux Pump-Specific Determinant to Fight Against the Antimicrobial Resistance in Pathogenic Strains
H Meena, B Siddhardha - Current Chemical Biology, 2018 - ingentaconnect.com
Background: Due to increased use of antimicrobials, pathogenic bacteria have pioneered
their own intrinsic resistance for antibiotics that raise the demand of inventing new …
their own intrinsic resistance for antibiotics that raise the demand of inventing new …
[HTML][HTML] Phytocompounds as potential inhibitors of mycobacterial multidrug efflux pump Rv1258c: an in silico approach
SS Biswas, JD Roy - AMB Express, 2024 - Springer
The number of infections and deaths caused by multidrug resistant (MDR) tuberculosis is
increasing globally. One of the efflux pumps, that makes Mycobacterium tuberculosis …
increasing globally. One of the efflux pumps, that makes Mycobacterium tuberculosis …
[PDF][PDF] Computational docking in silico analysis of potential efflux pump inhibitor punigratane
Z Rafiq, S Sivaraj, R Vaidyanathan - Int. J. Pharm. Pharm. Sci, 2018 - academia.edu
Objective: Efflux-mediated resistance is a growing therapeutic complication as it reduces the
efficacy of antibiotics. In gram-negative bacteria like E. coli and K. pneumoniae, this can be …
efficacy of antibiotics. In gram-negative bacteria like E. coli and K. pneumoniae, this can be …
In-silico interaction studies suggest RND efflux pump mediates polymyxin resistance in Acinetobacter baumannii
P Verma, P Maurya, M Tiwari… - Journal of Biomolecular …, 2019 - Taylor & Francis
Bacterial efflux pumps have emerged as antibiotic resistance determinants and confers multi-
drug resistance to a broad range of antimicrobials as well as non-antibiotic substances. A …
drug resistance to a broad range of antimicrobials as well as non-antibiotic substances. A …
Inhibitors of multidrug efflux pumps of Pseudomonas aeruginosa from natural sources: An in silico high-throughput virtual screening and in vitro validation
G Mangiaterra, E Laudadio, M Cometti… - Medicinal Chemistry …, 2017 - Springer
Pseudomonas aeruginosa is resistant to a wide range of antibiotics, thus making
troublesome the infection treatment. Efflux systems are the main mechanisms involved; …
troublesome the infection treatment. Efflux systems are the main mechanisms involved; …
Docking analysis insights quercetin can be a non-antibiotic adjuvant by inhibiting Mmr drug efflux pump in Mycobacterium sp. and its homologue EmrE in Escherichia …
B Suriyanarayanan… - Journal of Biomolecular …, 2015 - Taylor & Francis
Drug efflux pumps (EP) like Mmr in Mycobacterium transported drugs out of cell, a main
reason for drug resistance developing in Mycobacterium tuberculosis. In this in silico study …
reason for drug resistance developing in Mycobacterium tuberculosis. In this in silico study …
Discovery of novel dihydronaphthalene—imidazole ligands as potential inhibitors of Staphylococcus aureus multidrug resistant NorA efflux pump: A combination of …
AA Malik, NA Dangroo, P Kaur, S Attery, MA Rather… - Microbial …, 2024 - Elsevier
Overexpression of the efflux pump is a predominant mechanism by which bacteria show
antimicrobial resistance (AMR) and leads to the global emergence of multidrug resistance …
antimicrobial resistance (AMR) and leads to the global emergence of multidrug resistance …