[HTML][HTML] 3D-Pharmacophore and Molecular Docking Studies for AcrAB-TolC Efflux Pump Potential Inhibitors from DrugBank and Traditional Chinese Medical …

TV Phan - Open Access Macedonian Journal of Medical Sciences, 2022 - oamjms.eu
Background: Due to the widespread resistance to several antibiotics, the AcrAB-TolC
tripartite efflux pump is the primary multi-drug efflux system of Escherichia coli. One of the …

Virtual screening and biological activity evaluation of novel efflux pump inhibitors targeting AdeB

Y Tuo, Y Tang, R Yang, XM Zhao, M Luo, X Zhou… - International Journal of …, 2023 - Elsevier
The AdeABC efflux pump is an important mechanism causing multidrug resistance in
Acinetobacter baumannii, and its main component AdeB can recognize carbapenems …

The search of potential inhibitors of the AcrAB–TolC system of multidrug-resistant Escherichia coli: an in silico approach

H Abdel-Halim, A Al Dajani, A Abdelhalim… - Applied microbiology …, 2019 - Springer
The number of infections caused by multidrug antibiotic resistance (MDR) species is
increasing globally. The efflux pump system, AcrAB–TolC, confers Escherichia coli …

[HTML][HTML] Enhanced Efficacy of Ciprofloxacin and Tobramycin against Staphylococcus aureus When Combined with Corydalis Tuber and Berberine through Efflux …

Y Seo, M Kim, TJ Kim - Antibiotics, 2024 - mdpi.com
One way that bacteria develop antibiotic resistance is by reducing intracellular antibiotic
concentrations through efflux pumps. Therefore, enhancing the efficacy of antibiotics using …

[HTML][HTML] Terpenes as bacterial efflux pump inhibitors: A systematic review

KJSDO Dias, GM Miranda, JR Bessa… - Frontiers in …, 2022 - frontiersin.org
Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While
molecular analyses have identified efflux pump expression as an essential mechanism …

Rejuvenating the Potential of Antimicrobials Via Targeted Therapy of Efflux Pumps: The Advent of Phytotherapeutics

T Biswas, M Ahmed, S Mondal - Medicinal Plants and Antimicrobial …, 2024 - Springer
Antimicrobial resistance (AMR) and the emergence of multidrug-resistant organisms are one
of the most eminent impediments of recent times. The intrinsic resistance mechanisms of the …

[PDF][PDF] Synergistic effect of silver nanoparticles and streptomycin antibiotic on the MexX gene expression of pump efflux system in drug-resistant Pseudomonas …

A Mohammad, F Molavi… - Journal of Ilam University …, 2022 - sjimu.medilam.ac.ir
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Author(s) Publisher: Ilam University of Medical Sciences Journal of Ilam University of Medical …

Potential inhibitory properties of selected plant secondary metabolites from local plant families in the Philippines against AcrAB-TolC drug efflux pump system of E. coli …

DIA Segui, RJP Gandia, RJP Pizarro… - Journal of …, 2022 - phytojournal.com
Antibiotics heralded an approach to controlling and ending infectious diseases caused by
bacteria. However, these life-saving drugs have begun to lose their efficacy as various …

Efflux Pump. Mediated Resistance in Chemotherapy

PO Ughachukwu, PC Unekwe - Annals of medical and health sciences …, 2012 - ajol.info
Efflux pump mechanisms perform important physiological functions such as prevention of
toxin absorption from the gastrointestinal tract, elimination of bile from the hepatocytes …

Efflux-mediated ciprofloxacin and cefixime resistance in Pseudomonas aeruginosa

M Mini, AP Sreekantan, AK Manikandan… - Environmental and …, 2022 - journal.lu.lv
Pseudomonas aeruginosa is a gram-negative, motile and clinically relevant bacterium. It is a
significant pathogen associated with immunosuppression, cystic fibrosis and malignancy …