Acinetobacter baumannii is an ESKAPE pathogen known to cause fatal nosocomial
infections. With the surge of multidrug resistance (MDR) in the bacterial system, effective …

Abstract Resistance-Nodulation-Division (RND) efflux pumps are responsible for multidrug
resistance in Pseudomonas aeruginosa. The present study aimed to evaluate the …

Chalcones have an open chain flavonoid structure that can be obtained from natural
sources or by synthesis and are widely distributed in fruits, vegetables, and tea. They have a …

Plants contain many bioactive compounds with potent antibacterial and efflux pump
inhibitory activity (EPI). In this study, gallic acid extracted from pomegranate molasses by …

Antimicrobial resistance (AMR) is a complex threat to human health and, to date, it
represents a hot topic in drug discovery. The use of non-antibiotic molecules to block …

In recent years, due to the uncontrolled use of antibiotics and natural evolution, many
pathogenic microorganisms have acquired resistance to currently available drugs …

Background Antimicrobial resistance is considered a major concern problem; bacteria have
evolved mechanisms to overcome antibiotics' action through evolutionary process. One …

The cases of bacterial multidrug resistance are increasing every year and becoming a
serious concern for human health. Multidrug efflux pumps are key players in the formation of …

Multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa are the two
bacteria notorious for nosocomial infections and threats in healthcare settings. Efflux pump …

ABSTRACT Objective: Overexpression of AcrAB-TolC protein complex is often associated
with the virulence of multidrug-resistant bacteria. Development of an effective efflux pump …