Phosphodiesterase type-5 (PDE5) inhibitors are widely used as first-line therapy for erectile
dysfunction (ED). Their efficacy and safety combined with an increasing understanding of …

Abstract The phosphodiesterase type-5 (PDE5) inhibitors sildenafil, vardenafil and tadalafil
are widely used first-line therapy for erectile dysfunction (ED). Since the advent of sildenafil …

The phosphodiesterase type-5 inhibitors (PDE5-Is) sildenafil, vardenafil and tadalafil are
widely used as first-line therapy for erectile dysfunction (ED). Since the approval of sildenafil …

Phosphodiesterase (PDE) enzymes are widely distributed throughout the body, having
numerous effects and functions. The PDE type 5 (PDE5) inhibitors are widely used to treat …

PDE-5 inhibitors were originally studied in cardiovascular indications but were later
developed and approved for on-demand treatment of erectile dysfunction (ED). A few years …

Introduction: The inhibition of cyclic nucleotide PDE5 has been clinically validated as an
effective treatment for erectile dysfunction and pulmonary arterial hypertension. There are …

OBJECTIVE: Review the literature on phosphodiesterase type 5 inhibitors (PDE5-Is),
addressing critical issues in their current and future use, assessing unanswered questions …

PDE5 inhibitors have been clearly established as first-line therapy for the treatment of
erectile dysfunction (ED). Three PDE5 inhibitors-sildenafil (Viagra®), vardenafil (Levitra®) …

ABSTRACT Introduction Phosphodiesterase type 5 (PDE5) inhibitors are widely used as first-
line therapy for erectile dysfunction (ED). Their efficacy and safety combined with an …

A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug which works by
blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on …