Post‐Synthetic Modification of Triplex‐Forming Oligonucleotides Containing 2‐Aminoethyl‐2′‐Deoxynebularine Derivatives
R Notomi, S Sasaki, Y Taniguchi - Current Protocols, 2023 - Wiley Online Library
This article describes the detailed synthetic protocol for the preparation of oligonucleotides
containing 2‐guanidinoethyl‐2′‐deoxynebularine and 2‐ureidoethyl‐2 …
containing 2‐guanidinoethyl‐2′‐deoxynebularine and 2‐ureidoethyl‐2 …
Conformationally restricted triplex-forming oligonucleotides (TFOs). Binding properties of α-l-LNA and introduction of the N7-glycosylated LNA-guanosine
AA Koshkin - Tetrahedron, 2006 - Elsevier
The method for scaled-up production of α-l-LNA phosphoramidite building blocks containing
thymine and 5-methylcytosine nucleobases is described. Binding properties of pyrimidine …
thymine and 5-methylcytosine nucleobases is described. Binding properties of pyrimidine …
Synthesis of 7'‐Substituted 2'‐O‐4'‐C‐Ethylene Bridged Nucleic Acid (ENA)‐Thymidine Monomers
P Sunchu, S Gaurrand, É Lambert… - European Journal of …, 2024 - Wiley Online Library
Abstract Derivatives of 2'‐O‐4'‐C‐Ethylene‐bridged Nucleic Acid (ENA) monomer, a
nucleoside used in the preparation of antisense modified oligonucleotides and featuring an …
nucleoside used in the preparation of antisense modified oligonucleotides and featuring an …
Synthesis and hybridizing properties of isoDNAs including 3′-O, 4′-C-ethyleneoxy-bridged 5-methyluridine derivatives
T Osawa, Y Hitomi, S Wakita, H Kim, Y Ito… - Bioorganic & Medicinal …, 2018 - Elsevier
Abstract 3′, 4′-Ethyleneoxy-bridged 5-methyluridine derivatives with methyl groups in the
bridge,(R)-Me-3′, 4′-EoNA-T and (S)-Me-3′, 4′-EoNA-T, were synthesized, and these …
bridge,(R)-Me-3′, 4′-EoNA-T and (S)-Me-3′, 4′-EoNA-T, were synthesized, and these …
Synthesis of oligonucleotides containing 7‐(2‐deoxy‐β‐d‐erythro‐pentofuranosyl)guanine and 8‐amino‐2′‐deoxyguanosine
TS Rao, RH Durland… - Journal of heterocyclic …, 1994 - Wiley Online Library
The synthesis of oligonucleotides containing 7‐(2‐deoxy‐β‐D‐erythro‐pentofuranosyl)
guanine and 8‐amino‐2′‐deoxyguanosine was accomplished. The viable intermediate N2 …
guanine and 8‐amino‐2′‐deoxyguanosine was accomplished. The viable intermediate N2 …
Synthesis and evaluation of a series of 1-(3-alkyl-2, 3-dideoxy-α, β-D-erythro-pentofuranosyl) thymines
K Agyei-Aye, DC Baker - Carbohydrate research, 1988 - Elsevier
Abstract A series of 1-(3-alkyl-2, 3-dideoxy-α, β-d-erythro-pentofuranosyl) thymines (3′-
alkyl-3′-deoxythymidines) has been prepared from 5-O-(tert-butyldiphenylsilyl)-2, 3 …
alkyl-3′-deoxythymidines) has been prepared from 5-O-(tert-butyldiphenylsilyl)-2, 3 …
Preparation of covalently linked DNA-RNA hybrids and arabinocytidine containing DNA fragments
E de Vroom, H Roelen, CP Saris… - Nucleic acids …, 1988 - academic.oup.com
It will be demonstrated that 5′-O-DMT-N-acyl-deoxyribonucleosides, 5′-O-Lev-2′-O-
MTHP-N-acyl-ribonucleosidea and, also, 2′-O-MTHP-N-acyl-ara-cyti-dine can be coupled …
MTHP-N-acyl-ribonucleosidea and, also, 2′-O-MTHP-N-acyl-ara-cyti-dine can be coupled …
Synthesis and properties of triple helix-forming oligodeoxyribonucleotides containing 7-chloro-7-deaza-2′-deoxyguanosine
Y Aubert, L Perrouault, C Hélène… - Bioorganic & medicinal …, 2001 - Elsevier
Multiple incorporations of 7-chloro-7-deaza-2′-deoxyguanosine in place of 2′-
deoxyguanosine have been performed into a triple helix-forming oligodeoxyribonucleotide …
deoxyguanosine have been performed into a triple helix-forming oligodeoxyribonucleotide …
Nucleosides and Nucleotides. 204. Synthesis of Oligodeoxynucleotides Containing 6'α-[N-(Aminoalkyl)carbamoyloxy]-carbocyclic-thymidines and the Thermal …
Y Ueno, N Karino, A Matsuda - Bioconjugate Chemistry, 2000 - ACS Publications
To construct the nuclease-resistant oligodeoxynucleotides (ODNs) with natural
phosphodiester linkages, we synthesized ODNs that contain 6 'α-[N-(aminoalkyl) …
phosphodiester linkages, we synthesized ODNs that contain 6 'α-[N-(aminoalkyl) …
Oligonucleotides with 3-hydroxy-N-acetylprolinol as sugar substitute
G Ceulemans, A Van Aerschot, J Rozenski… - Tetrahedron, 1997 - Elsevier
Fully modified oligonucleotides were synthesised from the 3-O-phosphoramidites of
monomethoxytritylated trans-3-hydroxy-N-[(N6-benzoyladenin-9-yl)-acetyl]-prolinol [(2S, 3R) …
monomethoxytritylated trans-3-hydroxy-N-[(N6-benzoyladenin-9-yl)-acetyl]-prolinol [(2S, 3R) …