We have developed a novel technique for incorporation of sheep cardiac sarcoplasmic
reticulum (SR) Ca2+-release channels into planar phospholipid bilayers in order to …

Intracellular calcium (Ca2+) homeostasis in cardiac myocytes is an important determinant of
both contractile and electrophysiological function and is responsible for excitation …

The focus of this thesis is to address the location and distribution of the type 2 Ryanodine
Receptor (RyR2) in mammalian cardiac myocytes with respect to their function. These …

Abstract Ryanodine receptor 2 (RyR2) cDNA has been available for more than 15 years;
however, due to the complex nature of ligand gating in this channel, many aspects of …

The ryanodine receptor (RyR) is an ion channel composed of four identical subunits
mediating calcium efflux from the endo/sarcoplasmic reticulum of excitable and non …

Regulation of the cardiac ryanodine receptor (RyR2) by intracellular Ca2+ and Mg2+ plays a
key role in determining cardiac contraction and rhythmicity, but their role in regulating the …

We have tested the hypothesis that a high density of negative charge at the luminal mouth of
the RyR2 pore plays a pivotal role in the high cation conductance and limited selectivity …

Cardiac ryanodine receptors (RyR2s) are intracellular calcium (Ca2+) release channels
most abundantly expressed in the heart and brain. They are clustered in the …

Publisher Summary Signal Ca 2+ enters the cytoplasm of mammalian cells from either
extracellular space or the lumenal space of intracellular organelles, the source depending …