Central serotonin 3 receptors play an important role in the modulation of nociceptive neural activity of trigeminal subnucleus caudalis and nocifensive orofacial …

K Okamoto, A Kimura, T Donishi, H Imbe, E Senba… - Neuroscience, 2005 - Elsevier
The role of central serotonin 3 receptors on neural activities recorded from superficial
laminae of trigeminal subnucleus caudalis/upper cervical spinal cord junction region was …

Serotoninergic projections from the dorsal raphe nucleus to the nucleus submedius in the rat and cat

S Matsuzaki, M Takada, YQ Li, H Tokuno, N Mizuno - Neuroscience, 1993 - Elsevier
The nucleus submedius in the medial thalamus has been known to receive spinothalamic
and trigeminothalamic fibers, and to contain neurons which can be activated by noxious …

Pharmacological and neuroanatomical evidence for the involvement of the anterior pretectal nucleus in the antinociception induced by stimulation of the dorsal raphe …

MLNM Rosa, MA Oliveira, RB Valente, NC Coimbra… - Pain, 1998 - Elsevier
Several studies have shown that the anterior pretectal nucleus (APtN) is involved in
descending inhibitory pathways that control noxious inputs to the spinal cord and that it may …

Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine

DL Hammond, TL Yaksh - Brain research, 1984 - Elsevier
This study examined whether the antinociception produced by electrical stimulation of
medullary raphe nuclei is mediated by activation of monoaminergic neurons projecting to …

The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception

B Godínez-Chaparro, G Martínez-Lorenzana… - Neuropeptides, 2016 - Elsevier
The role of oxytocin (OXT) in pain modulation has been suggested. Indeed, hypothalamic
paraventricular nuclei (PVN) electrical stimuli reduce the nociceptive neuronal activity (ie …

Modulation of nociception by descending serotoninergic projections

J Sawynok - Serotoninergic Neurons and 5-HT Receptors in the …, 1997 - Springer
Hydroxytryptamine (5-HT) plays a multifaceted role in the regulation of nociceptive
transmission. Complexity arises from actions at multiple sites within the pain transmission …

Serotoninergic axonal contacts on identified cat spinal dorsal horn neurons and their correlation with nucleus raphe magnus stimulation

V Miletic, MJ Hoffert, MA Ruda… - Journal of …, 1984 - Wiley Online Library
This study examined the distribution of serotoninergic (5‐HT) immunoreactive axonal
contacts on spinal laminae I and II neurons by combining the intracellular horseradish …

Effect of electrolytic and neurotoxic lesions of the median raphe nucleus on anxiety and stress

T Andrade, FG Graeff - Pharmacology Biochemistry and Behavior, 2001 - Elsevier
To study the role played by 5-HT mechanisms of the MRN, behavioural and physiological
parameters were presently measured in rats having either electrolytic or 5, 7 …

Effects of isoflurane concentration on the activity of pontomedullary raphe and medial reticular neurons in the rat

CG Leung, P Mason - Brain research, 1995 - Elsevier
Neurons in the pontomedullary raphe magnus (RM) and adjacent nucleus reticularis
paragigantocellularis pars α (NRPGα) are thought to participate in the modulation of spinal …

Activation of serotonergic neurons in the raphe magnus is not necessary for morphine analgesia

K Gao, DO Chen, JR Genzen… - Journal of Neuroscience, 1998 - Soc Neuroscience
A wealth of pharmacological and behavioral data suggests that spinally projecting
serotonergic cells mediate opioid analgesia. A population of medullary neurons, located …