Synthesis and Cellular Uptake of 2'-Substituted Analogues of (E)-5-(2-[125I]Iodovinyl)-2'-deoxyuridine in Tumor Cells Transduced with the Herpes Simplex Type-1 …
KW Morin, ED Atrazheva, EE Knaus… - Journal of medicinal …, 1997 - ACS Publications
A useful synthetic methodology was developed to synthesize and radiolabel a series of (E)-5-
(2-[125I] iodovinyl) uracil nucleoside substrates for herpes simplex virus type-1 thymidine …
(2-[125I] iodovinyl) uracil nucleoside substrates for herpes simplex virus type-1 thymidine …
Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
J Balzarini, KW Morin, EE Knaus, LI Wiebe… - Gene …, 1995 - europepmc.org
(E)-5-(2-Iodovinyl)-2'-deoxyuridine (IVDU), its 2'-fluoro-substituted derivatives IVFRU (with
fluorine in the ribo configuration), IVFAU (with fluorine in the ara configuration), and the …
fluorine in the ribo configuration), IVFAU (with fluorine in the ara configuration), and the …
Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex …
J Balzarini, E De Clercq, A Verbruggen… - Molecular …, 1985 - ASPET
(E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU) and various structurally related analogues
thereof, ie,(E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) and (E)-5-(2-bromovinyl)-2' …
thereof, ie,(E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) and (E)-5-(2-bromovinyl)-2' …
Quantitative uptake studies of 131I-labeled (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells in vitro
MJ Gill, J Samuel, LI Wiebe, EE Knaus… - Antimicrobial agents …, 1984 - Am Soc Microbiol
We have synthesized a 131I-radiolabeled antiviral compound (E)-5-(2-iodovinyl)-2'-
deoxyuridine (IVdU) and shown that this agent was selectively trapped within rabbit kidney …
deoxyuridine (IVdU) and shown that this agent was selectively trapped within rabbit kidney …
In vivo comparison of IVDU and IVFRU in HSV1-TK gene expressing tumor bearing rats
TH Choi, SH Ahn, HC Kwon, CW Choi, OD Awh… - Applied radiation and …, 2004 - Elsevier
(E)-5-(2-Iodovinyl)-2′-deoxyuridine (IVDU) and (E)-5-(2-iodovinyl)-2′-fluoro-2′-
deoxyuridine (IVFRU) are potential substrates of Herpes Simplex Virus type 1thymidine …
deoxyuridine (IVFRU) are potential substrates of Herpes Simplex Virus type 1thymidine …
Mechanism of cytostatic action of novel 5-(thien-2-yl)-and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine …
C Bohman, J Balzarini, P Wigerinck… - Journal of Biological …, 1994 - Elsevier
Several novel 5-substituted 2'-deoxyuridine (dUrd) analogues were evaluated as substrates
for highly purified herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) …
for highly purified herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) …
Synthesis and antiviral activity of IVFRU, a potential probe for the non-invasive diagnosis of herpes simplex encephalitis.
T Iwashina, DR Tovell, LI Xu, DL Tyrrell… - Drug design and …, 1988 - europepmc.org
Synthesis of (E)-5-(2-iodovinyl)-1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl) uracil (IVFRU; 4a),
and its [125I] and [131I] derivatives (4b and 4c) are described. Compared with IVDU, IVFRU …
and its [125I] and [131I] derivatives (4b and 4c) are described. Compared with IVDU, IVFRU …
The cytostatic activity of 5‐(1‐azidovinyl)‐2′‐deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene‐transfected FM3A cells is due to inhibition of …
5‐(1‐Azidovinyl)‐2′‐deoxyuridine (AzVDU) and a series of 5‐[1‐azido‐2‐halogenoethyl]‐
derivatives of β‐d‐arabinofuranosyluracil (AU) proved markedly inhibitory to the replication …
derivatives of β‐d‐arabinofuranosyluracil (AU) proved markedly inhibitory to the replication …
Synthesis of (E)-5-(3, 3, 3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogs: potent and unusually selective antiviral activity of (E)-5-(3, 3, 3-trifluoro-1-propenyl …
DE Bergstrom, JL Ruth, PA Reddy… - Journal of medicinal …, 1984 - ACS Publications
Syntheses of CE)-5-(3, 3, 3-trifluoro-l-propenyl)-2'-deoxyuridine (TFPe-dUrd)(1), 5-(3, 3, 3-
trifluoro-l-propyl)-2'-deoxyuridine (11), 5-(3, 3, 3-trifluoro-l-methoxy-l-propyl)-2,-deoxyuridine …
trifluoro-l-propyl)-2'-deoxyuridine (11), 5-(3, 3, 3-trifluoro-l-methoxy-l-propyl)-2,-deoxyuridine …
Pharmacokinetics and metabolism of E-5-(2-[131I] iodovinyl)-2'-deoxyuridine in dogs
J Samuel, MJ Gill, T Iwashina, DR Tovell… - Antimicrobial agents …, 1986 - Am Soc Microbiol
E-5-(2-Iodovinyl)-2'-deoxyuridine (IVdU) is a potent inhibitor of herpes simplex virus type 1
replication in vitro. The selective antiviral activity of IVdU is due to preferential …
replication in vitro. The selective antiviral activity of IVdU is due to preferential …