Objective To determine how single nucleotide polymorphisms located on genes MDR1,
CYP3A4, and CYP3A5 affect the absorption kinetics of cyclosporine in cardiac transplant …

Objective Our objective was to determine the relationship between single nucleotide
polymorphisms (SNPs) in the multidrug resistance 1 (MDR‐1) gene and the cytochrome …

Background The immunosuppressive drug cyclosporine (INN, ciclosporin), whose
pharmacokinetic characteristics vary greatly among individuals, is a substrate for …

SUMMARY 1 The calcineurin inhibitor cyclosporine is widely used to prevent allograft
rejection after solid organ transplantation. It has a narrow therapeutic index and shows …

This retrospective study investigated the impact of MDR1 haplotypes derived from the single‐
nucleotide polymorphisms (SNPs) 2677G> T (exon 21) and 3435C> T (exon 26) on the …

Objectives: Cyclosporine (CsA) has a narrow thera-peutic range, and its pharmacokinetic
characteristics vary among individuals. It also is a substrate for cytochrome P450 (CYP) 3A …

Abstract Intestinal cytochrome P 450 3A4 (CYP3A4) and P-glycoprotein (P-gp) both play a
vital role in the metabolism of oral cyclosporine (CsA). We investigated the genetic …

Objective The objective of this study was to retrospectively evaluate the effects of MDR1,
CYP3A4* 18B, and CYP3A5* 3 genetic polymorphisms on cyclosporine A (CsA) …

Cyclosporine is an immunosuppressive drug largely used in organ transplantation. It is
characterized by a narrow therapeutic index and wide interindividual variability in its …

BACKGROUND: Cyclosporine is often used to prevent allograft rejection in renal transplant
recipients. However, cyclosporine has a narrow therapeutic window and large variability in …