The fatality of cancer is mainly bestowed to the property of otherwise benign tumor cells to
become malignant and invade surrounding tissues by circumventing normal tissue barriers …

The calcium-binding protein S100A4 promotes metastasis in several experimental animal
models, and S100A4 protein expression is associated with patient outcome in a number of …

Elevated levels of the calcium-binding protein S100A4 promote metastasis and in carcinoma
cells are associated with reduced survival of cancer patients. S100A4 interacts with target …

The calcium-binding protein S100A4 can induce a metastatic phenotype in animal model
systems and its expression in various human cancers has been shown to be associated with …

S100A4, an important member of the S100 family of proteins, is best known for its significant
role in promoting cancer progression and metastasis. In addition to its expression in tumors …

The role of S100A4 in tumor progression and metastasis is well documented in numerous
research articles and summarized in several reviews [1-3]. Currently S100A4 is categorized …

Metastasis is the leading cause of cancer-related death and directly associates with cancer
progression, resistance to anticancer therapy, and poor patient survival. Current efforts …

Owing to the exceptional intracellular distribution and the heterogeneous expression pattern
during transformation and metastasis in various tumors, the EF-hand calcium-binding …

S100A4 (also known as Mts1, metastasin, p9Ka, pEL98, CAPL, calvasculin, Fsp-1, placental
calcium-binding protein) belongs to the family of EF-hand calcium-binding proteins, whose …

Abstract S100A8 and S100A9 are Ca 2+ binding proteins that belong to the S100 family.
Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in …