BACKGROUND: Cysteinyl leukotrienes and their receptors have been shown to be involved
in the generation of neuropathic pain. We performed this study to determine the antagonistic …

AIMS: Ischemia-reperfusion (I/R) event in vascular and nervous system has been
documented to rising ischemic and vasculitic neuropathic pain, clinically resembles the …

Objective The leukotrienes are inflammatory mediators. In the present study, the analgesic
role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible …

BACKGROUND: Tumor necrosis factor α (TNF-α) could trigger p38 mitogen-activated
protein kinase (MAPK) activation. Conversely phosphorylated p38 (p-p38) could induce the …

Background and objectives Neuropathic pain is partially refractory to currently available
treatments. Although some studies have reported that apoptosis signal-regulating kinase 1 …

Methods Twenty-four male Sprague–Dawley rats were randomly allocated to three groups
(eight per group): sham-operated (control) group, a neuropathic pain and normal saline …

Background This study aimed to investigate the potential mechanism of paeonol in the
treatment of neuropathic pain. Methods Relevant mechanisms were explored through …

The purpose of this review is to summarize the recent studies examining the expression of
leukotrienes (LTs) and their receptors in nociceptive pathways, and their crucial roles in …

Spinal cord injury (SCI) leads to an inflammatory response that generates substantial
secondary damage within the tissue besides the primary damage. Leukotrienes are …

Reports suggest that microglia play a key role in spinal nerve ligation (SNL)-induced
neuropathic pain, and toll-like receptor 3 (TLR3) has a substantial role in the activation of …