This study shows that HIV-specific cervical T cells can be isolated by cytobrushing and in
vitro polyclonal expansion is a useful approach to increase the number of T cells available …

HIV‐specific T cells that produce interferon‐γ (IFN‐γ) are present in the genital tract of HIV‐
infected women although these do not provide protection against genital HIV shedding …

Distinct HIV variants occur at the genital mucosa compared to in blood, which may similarly
result in differences in HIV T cell responses. There have been no studies of the maturational …

Human immunodeficiency virus (HIV)‐specific T‐cell responses are detectable in the female
genital tract of HIV‐infected women but little is known about their frequency or the factors …

In blood, the accumulation of terminally differentiated (TD) T cells during HIV infection is
associated with CD4 T cell loss and HIV disease progression. Here, we investigated the …

The HIV pandemic disproportionately affects women, with most infections acquired through
receptive vaginal sex. Although the target cells by which HIV establishes infection in the …

Background: CD8 T lymphocytes are important in HIV-1 control and mediate virus-specific
immunity in the blood and genital tract. The induction and monitoring of mucosal CD8 cell …

Background: The mucosal lymphocyte population is the largest in the body, and the
gastrointestinal compartment has been well characterized in HIV infection. Much less is …

The primary aim of this thesis was to examine whether HIV-1 specific T cell responses in HIV-
1 exposed seronegative (HESN) subjects could be firstly detected and if so, conferred …

The female genital tract is a portal of entry for sexual HIV transmission and a possible viral
reservoir. In this study, the ectocervical CD8+ T cell distribution was explored in situ and was …