Novel ketone body therapy for managing Alzheimer's disease - Puchowicz - 2017 - Journal of
Neurochemistry - Wiley Online Library Skip to Article Content Skip to Article Information Wiley …

In patients with Alzheimer's disease (AD) and in a triple transgenic (3xTg AD) mouse model
of AD low glucose metabolism in the brain precedes loss of memory and cognitive decline …

An early feature of Alzheimer's disease (AD) is region-specific declines in brain glucose
metabolism. Unlike other tissues in the body, the brain does not efficiently metabolize fats; …

Ketogenic diet and ketone bodies gained significant attention in recent years due to their
ability to influence the specific energy metabolism and restoration of mitochondrial …

Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …

Because of a decreased sensitivity toward insulin, a key regulator of pyruvate
dehydrogenase (PDH), Alzheimer's patients have lower brain glucose utilization with …

11. Cervenka, MC, B. Henry, J. Nathan, S. Wood, and JS Volek. 2013. Worldwide dietary
therapies for adults with epilepsy and other disorders. J. Child Neurol. 28: 1034–1040. 12 …

Background Providing ketone bodies to the brain can bypass metabolic blocks to glucose
utilization and improve function in energy-starved neurons. For this, plasma ketones must be …

Alzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and
neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for …

Ketone bodies (KBs), such as acetoacetate and β-hydroxybutyrate, serve as crucial
alternative energy sources during glucose deficiency. KBs, generated through ketogenesis …