Nearly all physiological cell deaths in animals proceed by the process of apoptosis, during
which the dying cells vanish without a trace, silently cleared without any accompanying …

This series of Reviews on cell death explores the creation of new therapies for correcting
excessive or deficient cell death in human disease. Signal transduction pathways controlling …

Apoptosis, a cell death programme mediated by the caspase family of cysteine proteases, is
essential for appropriate removal of excess cells in many developmental and physiological …

▪ Abstract Regulation of the homeostatic balance between cell proliferation and cell death is
essential for development and maintenance of multicellular organisms. Physiologic, or …

The process of programmed cell death, or apoptosis, is generally characterized by distinct
morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is …

Apoptosis is a carefully orchestrated and tightly controlled form of cell death, conserved
across metazoans. As the executioners of apoptotic cell death, cysteine-dependent …

Publisher Summary This chapter provides an overview of several recent advances in the
study of apoptosis, integrating the molecular events with the physiological and …

Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied
regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially …

Caspases are well known for their role as executioners of apoptosis. However, recent
studies have revealed that these lethal enzymes also have important mitogenic functions …

Programmed cell death (PCD) plays a fundamental role in animal development and tissue
homeostasis. Abnormal regulation of this process is associated with a wide variety of human …