Roles for cell death in development, homeostasis, and the control of infections and cancer
have long been recognized. Although excessive cell damage results in passive necrosis …

Defects in the regulation of apoptosis (programmed cell death) contribute to many diseases,
including pathologies associated with cell loss (eg stroke, heart failure, neurodegeneration …

Apoptosis plays an important role in development and maintenance of tissue homeostasis.
Intensive efforts have been made to explore the molecular mechanisms of the apoptotic …

Apoptosis is a morphologically stereotyped form of cell death, prevalent in multicellular
organisms, by which single cells are deleted from the midst of living tissues. Recognition of …

Underneath the intricacy of every cancer lies mysterious events that impel the tumour cell
and its posterity into abnormal growth and tissue invasion. Oncogenic mutations disturb the …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Cell death is a major mechanism to eliminate cells in which DNA is damaged, organelles
are stressed, or oncogenes are overexpressed, all events that would otherwise predispose …

Apoptosis is dependent upon caspase activation leading to substrate cleavage and,
ultimately, cell death. Although required for the apoptotic phenotype, it has become apparent …

Apoptosis, the most extensively studied form of programmed cell death, is essential for
organismal homeostasis. Apoptotic cell death has widely been reported as a tumor …

Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a
homeostatic balance between cell formation and cell death. It is a vital process for normal …