Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm,
are the largest protein structures of the nuclear envelope. In addition to their role in …

In eukaryotic cells, the genetic material is segregated inside the nucleus. This
compartmentalization of the genome requires a transport system that allows cells to move …

Highlights•Nuclear pore complexes and nucleoporins have many transport-independent
functions.•Nuclear pore complexes play key roles in gene expression regulation.•In yeast …

In addition to their established roles in nucleocytoplasmic transport, the intimate association
of nuclear pore complexes (NPCs) with chromatin has long led to speculation that these …

The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that
mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal …

The nuclear pore complex (NPC) is a massive nuclear envelope-embedded protein
complex, the canonical function of which is to mediate selective nucleocytoplasmic transport …

Eukaryotic cell function depends on the physical separation of nucleoplasmic and
cytoplasmic components by the nuclear envelope (NE). Molecular communication between …

Functional compartmentalization of the genome relies on interactions between genomic
regions and various nuclear scaffolds and macro-complexes. The Nuclear Pore Complex …

Nuclear pore complexes (NPCs) mediate all selective bidirectional transport between the
nucleus and the cytoplasm. Additional functions for NPCs and their constituent proteins …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …