Mechanisms of alcoholic heart disease

J Ren, LE Wold - Therapeutic advances in cardiovascular …, 2008 - journals.sagepub.com
Compromised heart function is regularly seen in patients with chronic alcohol ingestion and
is often manifested as cardiomegaly, reduced myocardial contractility (with concomitant …

Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress

X Zhang, SY Li, RA Brown, J Ren - Alcohol, 2004 - Elsevier
Alcoholic cardiomyopathy is characterized by cardiomegaly, disruptions of myofibrillary
architecture, reduced myocardial contractility, decreased ejection fraction, and enhanced …

Experimental assessment of the role of acetaldehyde in alcoholic cardiomyopathy

NS Aberle, J Ren - Biological procedures online, 2003 - Springer
Alcoholism is one of the major causes of non-ischemic heart damage. The myopathic state
of the heart due to alcohol consumption, namely alcoholic cardiomyopathy, is manifested by …

Alcoholic cardiomyopathy: pathophysiologic insights

MR Piano, SA Phillips - Cardiovascular toxicology, 2014 - Springer
Alcoholic cardiomyopathy (ACM) is a specific heart muscle disease found in individuals with
a history of long-term heavy alcohol consumption. ACM is associated with a number of …

The deleterious effects of alcohol on the heart: involvement of protein turnover

VR Preedy, T Siddiq, H Why… - Alcohol and …, 1994 - academic.oup.com
Ethanol ingestion can induce a variety of metabolic changes in the heart, and recent studies
have even suggested that moderate ethanol intake confers cardio-protective effects in …

Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models

J Ren - Acetaldehyde‐Related Pathology: Bridging the Trans …, 2006 - Wiley Online Library
Alcoholic cardiomyopathy is manifested as ventricular dysfunction although its pathogenesis
remains obscure. The major ethanol metabolite acetaldehyde is suspected to play a culprit …

A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy

Q Liang, EC Carlson, AJ Borgerding… - Journal of Pharmacology …, 1999 - ASPET
Chronic alcohol consumption produces alcoholic heart muscle disease (AHMD), a prevalent
form of congestive heart failure. Several hypotheses have been proposed to explain the …

The effects of ethanol on the heart: alcoholic cardiomyopathy

J Fernández-Solà - Nutrients, 2020 - mdpi.com
Alcoholic-dilated Cardiomyopathy (ACM) is the most prevalent form of ethanol-induced heart
damage. Ethanol induces ACM in a dose-dependent manner, independently of nutrition …

Alcohol effects on cardiac function

JD Gardner, AJ Mouton - Comprehensive Physiology, 2011 - Wiley Online Library
The consumption of ethanol can have both beneficial and detrimental effects on the function
of the heart and cardiovascular system, depending on the amount consumed. Low‐to …

Alcoholic heart disease: a review.

MR Piano, DW Schwertz - Heart & Lung: the Journal of Critical Care, 1994 - europepmc.org
The association between chronic alcohol consumption and alcoholic heart disease in
human beings is well recognized. Chronic alcohol consumption is the leading cause of …