Contribution of lectin-like oxidized low-density lipoprotein receptor-1 and LOX-1 modulating compounds to vascular diseases
A Hofmann, C Brunssen, H Morawietz - Vascular pharmacology, 2018 - Elsevier
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for
binding and uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells. LOX-1 is …
binding and uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells. LOX-1 is …
Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) in atherogenesis: a brief review
AB Reiss, K Anwar, P Wirkowski - Current medicinal chemistry, 2009 - ingentaconnect.com
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that
primarily binds and regulates oxidized low-density lipoprotein (LDL). Expression of LOX-1 is …
primarily binds and regulates oxidized low-density lipoprotein (LDL). Expression of LOX-1 is …
Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders
JL Mehta, J Chen, PL Hermonat, F Romeo… - Cardiovascular …, 2006 - academic.oup.com
Abstract LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …
Upregulated LOX-1 receptor: key player of the pathogenesis of atherosclerosis
Abstract Purpose of Review In any case, in proatherogenic conditions, LOX-1 is uniquely
upregulated in vascular cells and mediates the entire atherogenic process from LDL …
upregulated in vascular cells and mediates the entire atherogenic process from LDL …
LOX-1-mediated effects on vascular cells in atherosclerosis
DA Chistiakov, AN Orekhov… - Cellular Physiology and …, 2016 - karger.com
In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-
1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly …
1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly …
Lectin‐like oxidized low‐density lipoprotein receptor‐1, a new promising target for the therapy of atherosclerosis?
Endothelial activation and dysfunction induced by oxidized modified low‐density lipoprotein
(ox‐LDL) is one of the key steps in the initiation of atherosclerosis. Recent studies have …
(ox‐LDL) is one of the key steps in the initiation of atherosclerosis. Recent studies have …
LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis
M Chen, T Masaki, T Sawamura - Pharmacology & therapeutics, 2002 - Elsevier
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) was initially identified
as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression …
as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression …
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease
A Akhmedov, T Sawamura, CH Chen… - European heart …, 2021 - academic.oup.com
Cardiovascular diseases (CVDs), specifically lipid-driven atherosclerotic CVDs, remain the
number one cause of death worldwide. The lectin-like oxidized low-density lipoprotein (LDL) …
number one cause of death worldwide. The lectin-like oxidized low-density lipoprotein (LDL) …
Role of LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) as a cardiovascular risk predictor: mechanistic insight and potential clinical use
J Barreto, SK Karathanasis, A Remaley… - … , and vascular biology, 2021 - Am Heart Assoc
Atherosclerosis, the underlying cause of cardiovascular disease (CVD), is a worldwide
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …
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