Contribution of lectin-like oxidized low-density lipoprotein receptor-1 and LOX-1 modulating compounds to vascular diseases

A Hofmann, C Brunssen, H Morawietz - Vascular pharmacology, 2018 - Elsevier
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for
binding and uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells. LOX-1 is …

Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) in atherogenesis: a brief review

AB Reiss, K Anwar, P Wirkowski - Current medicinal chemistry, 2009 - ingentaconnect.com
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that
primarily binds and regulates oxidized low-density lipoprotein (LDL). Expression of LOX-1 is …

Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders

JL Mehta, J Chen, PL Hermonat, F Romeo… - Cardiovascular …, 2006 - academic.oup.com
Abstract LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …

Upregulated LOX-1 receptor: key player of the pathogenesis of atherosclerosis

S Singh, AS Gautam - Current atherosclerosis reports, 2019 - Springer
Abstract Purpose of Review In any case, in proatherogenic conditions, LOX-1 is uniquely
upregulated in vascular cells and mediates the entire atherogenic process from LDL …

LOX-1-mediated effects on vascular cells in atherosclerosis

DA Chistiakov, AN Orekhov… - Cellular Physiology and …, 2016 - karger.com
In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-
1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly …

Lectin‐like oxidized low‐density lipoprotein receptor‐1, a new promising target for the therapy of atherosclerosis?

XP Chen, TT Zhang, GH Du - Cardiovascular drug reviews, 2007 - Wiley Online Library
Endothelial activation and dysfunction induced by oxidized modified low‐density lipoprotein
(ox‐LDL) is one of the key steps in the initiation of atherosclerosis. Recent studies have …

LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis

M Chen, T Masaki, T Sawamura - Pharmacology & therapeutics, 2002 - Elsevier
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) was initially identified
as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression …

LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

S Xu, S Ogura, J Chen, PJ Little, J Moss… - Cellular and Molecular Life …, 2013 - Springer
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease

A Akhmedov, T Sawamura, CH Chen… - European heart …, 2021 - academic.oup.com
Cardiovascular diseases (CVDs), specifically lipid-driven atherosclerotic CVDs, remain the
number one cause of death worldwide. The lectin-like oxidized low-density lipoprotein (LDL) …

Role of LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) as a cardiovascular risk predictor: mechanistic insight and potential clinical use

J Barreto, SK Karathanasis, A Remaley… - … , and vascular biology, 2021 - Am Heart Assoc
Atherosclerosis, the underlying cause of cardiovascular disease (CVD), is a worldwide
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …