Aims/hypothesis While it is well known that diet-induced obesity causes insulin resistance,
the precise mechanisms underpinning the initiation of insulin resistance are unclear. To …

OBJECTIVE Tissue inflammation is a key factor underlying insulin resistance in established
obesity. Several models of immuno-compromised mice are protected from obesity-induced …

To elucidate cellular mechanisms of insulin resistance induced by excess dietary fat, we
studied conscious chronically high-fat–fed (HFF) and control chow diet-fed rats during …

High–fat (HF) diet-induced obesity and insulin insensitivity are associated with inflammation,
particularly in white adipose tissue (WAT). However, insulin insensitivity is apparent within …

Aims/hypothesis The mechanisms for diet-induced intramyocellular lipid accumulation and
its association with insulin resistance remain contentious. In a detailed time-course study in …

Chronic high-fat feeding in rats induces profound whole-body insulin resistance, mainly due
to effects in oxidative skeletal muscle. The mechanisms of this reaction remain unclear, but …

High-fat feeding for 3–4 days impairs glucose tolerance and hepatic insulin sensitivity.
However, it remains unclear whether the evolving hepatic insulin resistance is due to acute …

It is well described that excessive lipid metabolism can cause insulin resistance in both
animals and humans, and this has been implicated as a causative factor in the development …

Exposure to high vs. low glycemic index (GI) diets increases fat mass and insulin resistance
in obesity-prone C57BL/6J mice. However, the longer-term effects and potentially involved …

Abstract High-fat (HF)-diet rodent models have contributed significantly to the analysis of the
pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly …