Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling

Y Zhao, X Ye, R Chen, Q Gao, D Zhao… - Oncology …, 2020 - spandidos-publications.com
Increasing evidence has indicated the roles of sirtuin 7 (SIRT7) in numerous human
cancers. However, the effects and the clinical significance of SIRT7 in human lung cancer is …

[HTML][HTML] Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway

L Bai, G Lin, L Sun, Y Liu, X Huang, C Cao, Y Guo… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Sirtuin6 (SIRT6), a member of the sirtuins protein family, plays multiple complex
roles in cancer. Here, we report that elevated SIRT6 expression was correlated with …

Retracted: Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway

H Lin, Y Hao, Z Zhao, Y Tong - FEBS Open Bio, 2017 - Wiley Online Library
Dysregulation of sirtuin 6 (SIRT6) is actively involved in tumor progression. High levels of
SIRT6 have been associated with hepatocellular carcinoma and non‐small cell lung cancer …

[HTML][HTML] Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines

V Krishnamoorthy, R Vilwanathan - Genomics, 2020 - Elsevier
Abstract Sirtuins (SIRT1–7), are NAD-dependent deacetylases and ADP-ribosyl
transferases, plays a major part in carcinogenesis. The previous report suggests that in …

The expression and related clinical significance of SIRT3 in Non‐small‐cell lung cancer

GC Yang, BC Fu, DY Zhang, L Sun, W Chen… - Disease …, 2017 - Wiley Online Library
Objective. To examine the relationship between the Sirtuin‐3 (SIRT3) expression and the
clinical indicators/prognosis of patients with non‐small‐cell lung cancer (NSCLC). Methods …

[HTML][HTML] Sirtuin7 has an oncogenic potential via promoting the growth of cholangiocarcinoma cells

W Li, Z Sun, C Chen, L Wang, Z Geng, J Tao - Biomedicine & …, 2018 - Elsevier
Accumulating evidence indicates that sirtuin7 (SIRT7) plays an oncogenic role in the main
types of liver cancer, hepatocellular carcinoma (HCC). Nevertheless, the clinical significance …

Regulation of SIRT2 levels for human non-small cell lung cancer therapy

Z Li, QR Xie, Z Chen, S Lu, W Xia - Lung Cancer, 2013 - Elsevier
Seven Sirtuin family members (SIRT1-7), comprising a family of NAD+-dependent protein
deacetylases and ADP-ribosyltransferases, are key proteins that regulate multiple …

SIRT1 expression is associated with poor prognosis of lung adenocarcinoma

C Li, L Wang, L Zheng, X Zhan, B Xu… - OncoTargets and …, 2015 - Taylor & Francis
Several studies have reported that the overexpression of Sirtuin 1 (SIRT1) was associated
with poor prognosis in various human cancers. However, little is known regarding the …

[HTML][HTML] Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression

W Wei, ZX Jing, Z Ke, P Yi - American Journal of Cancer Research, 2017 - ncbi.nlm.nih.gov
It is still a controversy whether the role of Sirtuin 7 (SIRT7) is an oncogene or a tumor
suppressor gene in cancer as SIRT7 may have different functions in different types of …

MicroRNA-3666-induced suppression of SIRT7 inhibits the growth of non-small cell lung cancer cells

H Shi, Y Ji, D Zhang, Y Liu, P Fang - Oncology Reports, 2016 - spandidos-publications.com
Abstract Sirtuin7 (SIRT7) plays an important role in many cancer types, but its function in non-
small cell lung cancer (NSCLC) remains unclear. This study investigated the biological role …