Motivation Viruses, the most abundant biological entities on earth, are important
components of microbial communities, and as major human pathogens, they are …

Viruses are the most abundant biological entities on earth, and play vital roles in many
aspects of microbial communities. As major human pathogens, viruses have caused huge …

Viral infections remain a serious global health issue. Metagenomic approaches are
increasingly used in the detection of novel viral pathogens but also to generate complete …

Background Identifying viral sequences in mixed metagenomes containing both viral and
host contigs is a critical first step in analyzing the viral component of samples. Current tools …

Background The recent development of metagenomic sequencing makes it possible to
massively sequence microbial genomes including viral genomes without the need for …

One consistent finding among studies using shotgun metagenomics to analyze whole viral
communities is that most viral sequences show no significant homology to known …

Genome sequencing technologies continue to develop with remarkable pace, yet analytical
approaches for reconstructing and classifying viral genomes from mixed samples remain …

Infectious disease metagenomics is driven by the question:“what is causing the disease?” in
contrast to classical metagenome studies which are guided by “what is out there?” In case of …

Viruses are ubiquitous in humans and various environments and continually mutate
themselves. Identifying viruses in an environment without cultivation is challenging; …

Background: Virus discovery using high-throughput next-generation sequencing has
become more commonplace. However, although analysis of deep next-generation …