Autism spectrum disorder: signaling pathways and prospective therapeutic targets
J Baranova, G Dragunas, MCS Botellho… - Cellular and molecular …, 2021 - Springer
Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …
group of neurodevelopmental diseases representing a severe burden to affected individuals …
[HTML][HTML] Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition caused by
interactions of environmental and genetic factors. Recently we showed that activation of the …
interactions of environmental and genetic factors. Recently we showed that activation of the …
Loss of G as6 and A xl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone …
Abstract The TAM (Tyro3, Axl, and MerTK) family of receptor tyrosine kinases (RTKs) and
their ligands, Gas6 and ProS1, are important for innate immune responses and central …
their ligands, Gas6 and ProS1, are important for innate immune responses and central …
All‐trans‐retinoic acid ameliorates experimental allergic encephalomyelitis by affecting dendritic cell and monocyte development
XX Zhan, Y Liu, JF Yang, GY Wang, L Mu… - …, 2013 - Wiley Online Library
Experimental allergic encephalomyelitis (EAE) can be induced in animal models by injecting
the MOG35–55 peptide subcutaneously. Dendritic cells (DCs) that are located at the …
the MOG35–55 peptide subcutaneously. Dendritic cells (DCs) that are located at the …
Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect
G Liu, W Zhang, J Guo, F Kong, S Zhou, S Chen… - Brain Research, 2018 - Elsevier
The four kinds of adenosine receptor subtypes (ARs), named as ARA1, ARA2A, ARA2B and
ARA3, have multiple biological functions. ARs are differently distributed across the body and …
ARA3, have multiple biological functions. ARs are differently distributed across the body and …
Dysregulation in IL-6 receptors is associated with upregulated IL-17A related signaling in CD4+ T cells of children with autism
Autism spectrum disorder (ASD) is a heterogeneous syndrome characterized by
dysregulations in speech and social interactions as well as repetitive and stereotypical …
dysregulations in speech and social interactions as well as repetitive and stereotypical …
Altered T cell responses in children with autism
P Ashwood, P Krakowiak, I Hertz-Picciotto… - Brain, behavior, and …, 2011 - Elsevier
Autism spectrum disorders (ASD) are characterized by impairment in social interactions,
communication deficits, and restricted repetitive interests and behaviors. A potential etiologic …
communication deficits, and restricted repetitive interests and behaviors. A potential etiologic …
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
PE Zarek, CT Huang, ER Lutz… - Blood, The Journal …, 2008 - ashpublications.org
Tissue-derived adenosine, acting via the adenosine A2A receptor (A2AR), is emerging as
an important negative regulator of T-cell function. In this report, we demonstrate that A2AR …
an important negative regulator of T-cell function. In this report, we demonstrate that A2AR …
Loss of adenylyl cyclase type-5 in the dorsal striatum produces autistic-like behaviors
H Kim, Y Lee, JY Park, JE Kim, TK Kim, J Choi… - Molecular …, 2017 - Springer
Autism spectrum disorders (ASDs) are a heterogeneous group of psychiatric illness
characterized by common core symptoms including sociability deficits and stereotyped …
characterized by common core symptoms including sociability deficits and stereotyped …
The utility of rodent models of autism spectrum disorders
MT Lázaro, P Golshani - Current opinion in neurology, 2015 - journals.lww.com
The utility of rodent models of autism spectrum disorders : Current Opinion in Neurology The
utility of rodent models of autism spectrum disorders : Current Opinion in Neurology Log in or …
utility of rodent models of autism spectrum disorders : Current Opinion in Neurology Log in or …